DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxc1b

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_571804.1	Gene:	foxc1b / 79375	ZFINID:	ZDB-GENE-010302-2	Length:	433	Species:	Danio rerio

Alignment Length:	316	Identity:	92/316 - (29%)
Similarity:	139/316 - (43%)	Gaps:	59/316 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVAR 517
            ||||||..||..||..:.||::||:|||.||::.:|:|| :..:|||||||||||||..|:||.|
Zfish    74 KPPYSYIALITMAIQNSSDKKITLNGIYQFIMERFPFYR-DNKQGWQNSIRHNLSLNECFVKVPR 137

  Fly   518 SQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR--SSQGFRPPYGMPRSAPVSPSHM--DNSRESS 578
            ...:|||||:|.:||||.....:.|:.:||:|  .....|......|....:|...  .::::..
Zfish   138 DDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVLREKEDRDRQGKDNPGQACEQDAQQPV 202

  Fly   579 PLQDIVLQSA------PGSPGMSLEQRAADPEIIYNSQ-NAHQQQQQQQQQQQQQTLS---NNSN 633
            .|:||..::.      ..:|.:|...:...|:....|. :...|.|..||.....|:.   ..|.
Zfish   203 KLRDIKTENGACTPPHDSTPPLSTVPKTESPDRSGGSACSGSPQSQTPQQAFSMDTIMTGLRGSP 267

  Fly   634 QYSSGSP-------------YYVTNQSSGVATP-------QTHVEGSAASGGGGGGGVGAL---- 674
            |:::..|             |..|.|.:..:.|       ..:::.::...|..|.|...|
Zfish   268 QHAAELPASRAALPGSVSLTYSPTPQPAHYSPPCGQPATYHCNMQATSLYTGDRGHGDDTLPEYT 332

  Fly   675 -----LALKRNHVMGGGASQHTLHQQQAVAQ---QQHSEIIYEELPTDYSGHIEAS 722
                 .::...|......|||.  ||..:|.   .|..|:          ||:.||
Zfish   333 NTTNASSISHPHQSSSQESQHL--QQNRLAPWYLNQSGEL----------GHLSAS 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	49/86 (57%)
foxc1b	NP_571804.1	Forkhead	74..160	CDD:278670	49/86 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..250		12/75 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..355		8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820