DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxj1a

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001070174.2	Gene:	foxj1a / 767737	ZFINID:	ZDB-GENE-060929-1178	Length:	458	Species:	Danio rerio

Alignment Length:	423	Identity:	107/423 - (25%)
Similarity:	155/423 - (36%)	Gaps:	151/423 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 AHLIAGDGPGIYSPL-----KISIPKKEQKSPYLSPTGTISAANSC--------PASPRQGFIQN 423
            :||:..|.|.  |||     .|.:|        |:| |..:||:.|        |:....|
Zfish    78 SHLMGSDAPS--SPLAGDPASIGMP--------LTP-GKPTAASFCRVPMFSALPSLVAHG---- 127

  Fly   424 QPNNYNNYGNNNTQDLFQTPSTASYNHNE--KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKH 486
                             ..|....|..|.  |||||||.||..|:.|:...::|||.||.:|..:
Zfish   128 -----------------HCPDEVDYKSNPHIKPPYSYATLICMAMQASKKTKITLSCIYKWITDN 175

  Fly   487 YPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSS 551
            :.|:| ..:..||||||||||||:.||||.|.:||||||.||:|||....:|::.:|||||
Zfish   176 FCYFR-HADPTWQNSIRHNLSLNKCFIKVPRQKDEPGKGGFWKIDPQYAERLLNEAYKKRR---- 235

  Fly   552 QGFRPPYGMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSP-----------GMSLEQ----RAA 601
               .||      ..::|:.....|.::....::.::...||           ..|.:|    |.|
Zfish   236 ---LPP------VQINPALQHRLRMNAQATGVISRNLSVSPESQQLLKDFEEATSADQNWDPRLA 291

  Fly   602 DPEII---------------YNSQNAHQQQQQQQQ---QQQQQTLS----------------NNS 632
            :..::               ||.:.....::....   ..:|:.||                |..
Zfish   292 EATMLSCWISGKGTNKRKQPYNHRTGKTPRRSSSPLLVMDEQEDLSSLRGNFDWDALLDSALNGE 356

  Fly   633 NQYSSGSPYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLHQQQA 697
            ...:.|||...|.|...:....||:....|.              ..|||:
Zfish   357 LSLNEGSPLSPTPQDEELMIRGTHISPQEAP--------------VENHVL-------------- 393

  Fly   698 VAQQQHSEIIYEELPTDYSGHIEASEEECVTTA 730
                         :.|..||..:..||..:.||
Zfish   394 -------------METQRSGDEDFDEETFLATA 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	48/86 (56%)
foxj1a	NP_001070174.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..99		8/22 (36%)
		Forkhead	142..228	CDD:278670	48/86 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..324		2/18 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950