Protein Alignment FoxK and FOXL2

DIOPT Version :10

• Sequence 1: NP_001261701.1
• Gene: FoxK / 39252
• FlyBaseID: FBgn0036134
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_075555.1
• Gene: FOXL2 / 668
• HGNCID: 1092
• Length: 376
• Species: Homo sapiens
• Alignment Length: 325
• Identity: 99/325 - (30%)
• Similarity: 137/325 - (42%)
• Gaps: 77/325 - (23%)

  Fly   389 SIPKKEQKS-PYLSP-TG-TISAANSCPASPRQGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNH 450
            |.|:.|..: ..|:| || |:......|.||.:|          ..|...|..  :.|..|
Human     4 SYPEPEDAAGALLAPETGRTVKEPEGPPPSPGKG----------GGGGGGTAP--EKPDPA---- 52

  Fly   451 NEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKV 515
             :||||||..||..||..:.:|:|||||||.:|:..:|:|.| ..||||||||||||||..||||
Human    53 -QKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEK-NKKGWQNSIRHNLSLNECFIKV 115

  Fly   516 ARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPRSAPVSPSHMDNSRESSPL 580
            .|......||::|.:|| :...:.:....:||:|..:.||||          |:|....:.
Human   116 PREGGGERKGNYWTLDP-ACEDMFEKGNYRRRRRMKRPFRPP----------PAHFQPGKG---- 165

  Fly   581 QDIVLQSAPGSP-GMSLEQRAAD-------PEIIYNSQNAHQQQQQQQQQQQQQTLSNNS---NQ 634
                |..|.|:. |..:....||       |:.:                  |....|||   .|
Human   166 ----LFGAGGAAGGCGVAGAGADGYGYLAPPKYL------------------QSGFLNNSWPLPQ 208

  Fly   635 YSSGSPYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLHQQQAVA 699
            ..|..||.....::..|.      .:||:...|.|..||...:|  .:.|..||.....:.|::|
Human   209 PPSPMPYASCQMAAAAAA------AAAAAAAAGPGSPGAAAVVK--GLAGPAASYGPYTRVQSMA 265

  Fly   700  699
            Human   266  265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA_FOXK	151..252	CDD:438740
		FH_FOXK	453..531	CDD:410800	44/77 (57%)
FOXL2	NP_075555.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		16/65 (25%)
		FH_FOXL2	54..142	CDD:410802	46/89 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	276..342