DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxe3

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001073150.2	Gene:	foxe3 / 570855	ZFINID:	ZDB-GENE-061214-6	Length:	422	Species:	Danio rerio

Alignment Length:	389	Identity:	104/389 - (26%)
Similarity:	156/389 - (40%)	Gaps:	85/389 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 PAGAAAHLIAGDGPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNNY 431
            ||.||:.::......:.||  :.:|.........:..|.:..|....:||             |.
Zfish    23 PAEAASPVVVSPNVSLDSP--VPLPPLALNHQARTKDGILIKAEPQGSSP-------------NT 72

  Fly   432 GNNNTQDLFQT----PSTASYNHNE-----KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHY 487
            .......|.||    |:|.|.....     ||||||..||..||:.:|:::|||.|||.||::.:
Zfish    73 DREEVVSLGQTEEHLPATGSRRRKRPVQRGKPPYSYIALIAMAIANSPERKLTLGGIYKFIMERF 137

  Fly   488 PYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR--- 549
            |:|| |.:|.|||||||||:||..|:|:.|....||||::|.:||.:.....:.|:.:||:|
Zfish   138 PFYR-ENSKKWQNSIRHNLTLNDCFVKIPREPGRPGKGNYWTLDPAAEDMFDNGSFLRRRKRFKR 201

  Fly   550 -----------SSQGFRPP------------------YGMPRSAPVSPSHMDNSRESSPL----- 580
                       ||..|.|.                  ||...:....|:.:.:.:.|:.:
Zfish   202 TDVSTYPGYMQSSSAFTPTPMGRQAYPNTLYPGVTSGYGSQLAGSPHPAMLHHYQASAGVTQGQA 266

  Fly   581 ----------QDIVLQSAPGSPGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQY 635
                      |..|:||.......||...|.|...:.:|.:.   ........|.|.::..||..
Zfish   267 RMFSIDNIISQQTVMQSGGDLNTQSLGLGAGDLGTMTSSCSV---STSDPTCFQTQAINPTSNML 328

  Fly   636 SSGSPYYVTNQSSGVATPQ----THVEGSAASGGGGGGG----VGALLALKRNHVMGGGASQHT 691
            |..:....:|.:|....|.    :|:.|...||...||.    .|..::|.  .|..|..:.||
Zfish   329 SRNTGSLASNMTSSYTYPSPTSPSHLSGVTQSGFSPGGSQVYCSGNRISLP--PVRSGSCADHT 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	45/86 (52%)
foxe3	NP_001073150.2	FH	103..191	CDD:214627	45/88 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820