DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FoxK and Foxo3

DIOPT Version :10

Sequence 1:NP_001261701.1 Gene:FoxK / 39252 FlyBaseID:FBgn0036134 Length:760 Species:Drosophila melanogaster
Sequence 2:NP_062714.1 Gene:Foxo3 / 56484 MGIID:1890081 Length:672 Species:Mus musculus


Alignment Length:571 Identity:127/571 - (22%)
Similarity:205/571 - (35%) Gaps:171/571 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 TPLPRDELHQQQLHHHQQQPHLQQQQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTAL 352
            :|:|...|..      :..|..:.|..|.   :...|||:.:.|..||         .|...||.
Mouse     7 SPVPLSPLEV------ELDPEFEPQSRPR---SCTWPLQRPELQASPA---------KPSGETAA 53

  Fly   353 HQQ--------------QQRSGSIVVAPPAGAAAHLIAGDGPGIY---SPLKISIPKKEQKSPYL 400
            ...              .:.|.::|:.  .|.::.|    |.|:.   |.:.::...::..|...
Mouse    54 DSMIPEEDDDEDDEDGGGRASSAMVIG--GGVSSTL----GSGLLLEDSAMLLAPGGQDLGSGPA 112

  Fly   401 SPTGTISAANSCPASPRQGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQA 465
            |..|.:|........|:|...|.||......|.         |...|...|.....|||.||.:|
Mouse   113 SAAGALSGGTPTQLQPQQPLPQPQPGAAGGSGQ---------PRKCSSRRNAWGNLSYADLITRA 168

  Fly   466 ISAAPDKQLTLSGIYSFIVKHYPYYR----KETNKGWQNSIRHNLSLNRYFIKVARSQDE-PGKG 525
            |.::|||:||||.||.::|:..||::    ..::.||:|||||||||:..|::|   |:| .||.
Mouse   169 IESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV---QNEGTGKS 230

  Fly   526 SFWRIDPDSG---------AKLIDHS--YKKRRQRSSQGFRPPYGMPRSAPVSPSHMD------- 572
            |:|.|:||.|         |..:|:|  |.|.|.|:::........|.||..|||.:.       
Mouse   231 SWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQAAPESADDSPSQLSKWPGSPT 295

  Fly   573 -----------------NSRES------SP------LQDIVLQSAPGSPGMSLEQRAADPEI--- 605
                             ||..|      ||      |.|:.....|.||.:.....:..|.:   
Mouse   296 SRSSDELDAWTDFRSRTNSNASTVSGRLSPILASTELDDVQDDDGPLSPMLYSSSASLSPSVSKP 360

  Fly   606 ----------IYNSQNAHQQQQQQQQQQQQQTLSNNSNQYS-------SGSPYYVTNQSSGVATP 653
                      :..:.|.:....:.........::...:|.|       .||.:..|.:|||:.:|
Mouse   361 CTVELPRLTDMAGTMNLNDGLAENLMDDLLDNIALPPSQPSPPGGLMQRGSSFPYTAKSSGLGSP 425

  Fly   654 QTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLHQQQAVAQQQH------------SEI 706
                             .|:.     |..:.|.:|.::|.|......|::            ::.
Mouse   426 -----------------TGSF-----NSTVFGPSSLNSLRQSPMQTIQENRPATFSSVSHYGNQT 468

  Fly   707 IYEELPTDYSGHIEASEEECVTTATDATVAKRPKYVSEVLXCVRIQKHRQN 757
            :.:.|.:|...|            :|..:.:....:|:....|..|..|:|
Mouse   469 LQDLLASDSLSH------------SDVMMTQSDPLMSQASTAVSAQNARRN 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxKNP_001261701.1 FHA_FOXK 151..252 CDD:438740
FH_FOXK 453..531 CDD:410800 38/82 (46%)
Foxo3NP_062714.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..85 18/97 (19%)
Required for mitochondrial import. /evidence=ECO:0000250|UniProtKB:O43524 80..108 5/33 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..152 11/50 (22%)
FH_FOXO3 156..238 CDD:410835 39/84 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..301 19/70 (27%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O43524 241..258 3/16 (19%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000250|UniProtKB:O43524 299..672 37/243 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..441 13/63 (21%)
FOXO_KIX_bdg 431..510 CDD:465228 14/89 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..583
FOXO-TAD 605..643 CDD:435506
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.