DRSC/TRiP Functional Genomics Resources

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Protein Alignment FoxK and Foxo1

DIOPT Version :10

Sequence 1:NP_001261701.1 Gene:FoxK / 39252 FlyBaseID:FBgn0036134 Length:760 Species:Drosophila melanogaster
Sequence 2:NP_062713.2 Gene:Foxo1 / 56458 MGIID:1890077 Length:652 Species:Mus musculus


Alignment Length:478 Identity:118/478 - (24%)
Similarity:168/478 - (35%) Gaps:166/478 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   358 RSGSIVVAPPAGAAAHLIAGD--GP--GIYSPLKISIPKKEQKSPYLSPTGTISAANSCP--ASP 416
            |:...|....|.||:..:.||  ||  |...|          ..|...|||.:|.....|  |:.
Mouse    83 RAPGCVAVAAAAAASRGLCGDFQGPEAGCVHP----------APPQPPPTGPLSQPPPVPPSAAA 137

  Fly   417 RQGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYS 481
            ..|.:..||.                 .|:|...|.....|||.||.:||.::.:|:||||.||.
Mouse   138 AAGPLAGQPR-----------------KTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYE 185

  Fly   482 FIVKHYPYYR----KETNKGWQNSIRHNLSLNRYFIKVARSQDE-PGKGSFWRIDPDSG------ 535
            ::||..||::    ..::.||:|||||||||:..||:|   |:| .||.|:|.::|:.|      
Mouse   186 WMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV---QNEGTGKSSWWMLNPEGGKSGKSP 247

  Fly   536 ---AKLIDHSYK--KRRQRSSQ-------GFRPPYGMPRSA----PVSP-SH----MDN------ 573
               |..:|::.|  |.|.|:::       |...|...|.|.    |.|| ||    .||      
Mouse   248 RRRAASMDNNSKFAKSRGRAAKKKASLQSGQEGPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRP 312

  Fly   574 -----------------------------------------------SRESSP------LQDIVL 585
                                                           |..|:|      |.::.|
Mouse   313 RTSSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAKMASTLPSLSEISNPENMENLLDNLNL 377

  Fly   586 QSAP--------GSPGMSLEQRA----ADPEIIYNSQNAH-------QQQQQQQQQQQQQTLSNN 631
            .|:|        .|||..::|..    |.|....||.:.:       |.......|...|||.::
Mouse   378 LSSPTSLTVSTQSSPGSMMQQTPCYSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQMPMQTLQDS 442

  Fly   632 SNQYSSGSPY---------YVTNQS-----------SGVATPQTHVEGSAASGGGGGGGVGALLA 676
            .:.|...:.|         .:|:.|           .|||.|.:.|.|.....|...........
Mouse   443 KSSYGGLNQYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQ 507

  Fly   677 LKRNHVMGGGASQHTLHQQQAVA 699
            ...|.:|...:..|..|.||..:
Mouse   508 ASHNKMMNPSSHTHPGHAQQTAS 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxKNP_001261701.1 FHA_FOXK 151..252 CDD:438740
FH_FOXK 453..531 CDD:410800 38/82 (46%)
Foxo1NP_062713.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..154 13/68 (19%)
FH_FOXO1 148..246 CDD:410834 43/100 (43%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 208..215 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..342 21/110 (19%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 231..234 1/2 (50%)
Nuclear localization signal. /evidence=ECO:0000250 248..250 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393 280..562 47/251 (19%)
Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200 360..456 22/95 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..410 6/26 (23%)
FOXO_KIX_bdg 420..501 CDD:465228 16/80 (20%)
Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471 459..463 0/3 (0%)
FOXO-TAD 594..630 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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