DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxh1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001017084.1	Gene:	foxh1 / 549838	XenbaseID:	XB-GENE-1194372	Length:	515	Species:	Xenopus tropicalis

Alignment Length:	378	Identity:	90/378 - (23%)
Similarity:	137/378 - (36%)	Gaps:	114/378 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 PPAHHL--PLQQQQQQQQPAH------HPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGAAAHL 374
            ||:..|  .:.|:|....|.|      .|.|     ||:         |.|
Frog    22 PPSLALLSSIYQEQVPAAPGHSYEQCAQPWP-----PLY---------REG-------------- 58

  Fly   375 IAGDGPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNNYGNNNTQDL 439
                  |.:||.:.|:..       ||| ||           ::|.........::.|.:.|  |
Frog    59 ------GTWSPDRGSMHG-------LSP-GT-----------QEGSCTQAEGTKDSLGGDET--L 96

  Fly   440 FQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRH 504
            .:.....:|:...||||||..:|...|..:|:|:|.||.|...:...:|:: |....||::||||
Frog    97 SRKSKKKNYHRYAKPPYSYLAMIALVIQNSPEKRLKLSQILKEVSTLFPFF-KGDYMGWKDSIRH 160

  Fly   505 NLSLNRYFIKVARSQDEP-GKGSFWRID----PDSGAKL--------------------IDHSYK 544
            |||.|..|.||.:...:| .||:||.:|    |....||                    |.|:||
Frog   161 NLSSNDCFKKVLKDPGKPQAKGNFWTVDVSRIPLDAMKLQNTALTRGGSDYFVQDLAPYILHNYK 225

  Fly   545 KRRQRSSQGFRPPYGMPRSAPVSP----SHMDNSRES-----------SPLQDIVLQSAPG---- 590
               ...:.....|:.||..|...|    .|..|:...           :.|||:.|...|.
Frog   226 ---YEHNVVVYAPHHMPSHASSLPLAEDPHQTNTGGKLNTSFMIDSLLNDLQDVDLPDVPRNIES 287

  Fly   591 ---SPGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSP 640
               ||.:::....:...::|......:..:.........|.|::|:..|:.||
Frog   288 QRISPAVAINNMWSSAPLLYPQSKPTRNGRGPGFSASHSTYSSSSSSISTISP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	38/111 (34%)
foxh1	NP_001017084.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..103		15/97 (15%)
		FH	110..188	CDD:238016	34/78 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..399		7/34 (21%)
		SMAD-interaction domain (SID)	377..503
		Fast/FoxH1 motif 1 (FM1). /evidence=ECO:0000255	402..406
		Fast/FoxH1 motif 2 (FM2). /evidence=ECO:0000255	412..418
		SMAD-interaction motif (SIM)	467..488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920