Protein Alignment FoxK and FOXP3

DIOPT Version :10

• Sequence 1: NP_001261701.1
• Gene: FoxK / 39252
• FlyBaseID: FBgn0036134
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_054728.2
• Gene: FOXP3 / 50943
• HGNCID: 6106
• Length: 431
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 92/437 - (21%)
• Similarity: 141/437 - (32%)
• Gaps: 174/437 - (39%)

  Fly   259 SSDAIDGHSPSLVVGGGGGVAG----GGAHV---IITPLPRDELHQQQL---------HHHQQQP 307
            :||.:....|      ||...|    ||||.   .:.|:|..:|....|         ......|
Human    32 ASDLLGARGP------GGTFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLP 90

  Fly   308 HLQQ--QQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGA 370
            |||.  |..||.         ..|.....||...|....|||...|:         |.:.||..|
Human    91 HLQALLQDRPHF---------MHQLSTVDAHARTPVLQVHPLESPAM---------ISLTPPTTA 137

  Fly   371 AAHLIAGDGPGIYSPLKI-------------------SIPKKEQ------KSPY----------- 399
            .........||:...:.:                   |.|:|:.      :|.|
Human   138 TGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWP 202

  Fly   400 ---------------------------------------------------------------LS 401
                                                                           |:
Human   203 GCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALT 267

  Fly   402 PTGTISAAN--SC---------PASPRQGFIQNQPNN--------YNNYGNNNTQDLFQTPSTAS 447
            ...::::::  ||         |..|.....:..|::        :.::||:...:.........
Human   268 KASSVASSDKGSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFK 332

  Fly   448 YNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYF 512
            : ||.:||::||.||..||..||:||.||:.||.:..:.:.::|... ..|:|:|||||||::.|
Human   333 F-HNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHP-ATWKNAIRHNLSLHKCF 395

  Fly   513 IKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYG 559
            ::|     |..||:.|.:|     :|  ...|||.||.|:...|..|
Human   396 VRV-----ESEKGAVWTVD-----EL--EFRKKRSQRPSRCSNPTPG 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA_FOXK	151..252	CDD:438740
		FH_FOXK	453..531	CDD:410800	32/77 (42%)
FOXP3	NP_054728.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68		12/41 (29%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:22678915	68..76		2/7 (29%)
		LXXLL motif. /evidence=ECO:0000269|PubMed:18354202	92..96		2/3 (67%)
		Interaction with ZFP90. /evidence=ECO:0000269|PubMed:23543754	106..198		18/100 (18%)
		Essential for transcriptional repressor activity and for interaction with KAT5 and HDAC7. /evidence=ECO:0000269|PubMed:17360565	106..190		16/92 (17%)
		Interaction with IKZF4. /evidence=ECO:0000250|UniProtKB:Q99JB6	149..199		5/49 (10%)
		FOXP-CC	193..260	CDD:465036	0/66 (0%)
		Leucine-zipper	239..260		0/20 (0%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:22678915	239..248		0/8 (0%)
		Interaction with RUNX1. /evidence=ECO:0000269|PubMed:17377532	278..336		8/58 (14%)
		FH_FOXP3	337..417	CDD:410840	35/92 (38%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22678915	414..417		1/2 (50%)