DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and FOXB2

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001013757.1	Gene:	FOXB2 / 442425	HGNCID:	23315	Length:	432	Species:	Homo sapiens

Alignment Length:	326	Identity:	92/326 - (28%)
Similarity:	128/326 - (39%)	Gaps:	90/326 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 PSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLS 507
            |..:||: ::||||||..|...||..:.:|.|.||.||.||::.:||||:.|.: ||||:|||||
Human     4 PGKSSYS-DQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIMERFPYYREHTQR-WQNSLRHNLS 66

  Fly   508 LNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR-----------------SSQGFR 555
            .|..|||:.|..|:|||||||.:.||.|....:.|:.:||:|                 |:.|..
Human    67 FNDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSFLRRRKRFKVLRADHTHLHAGSTKSAPGAG 131

  Fly   556 P-----------------------------PYGMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGS 591
            |                             |...|...|..|.||.:.....|      .:||..
Human   132 PGGHLHPHHHHHPHHHHHHHAAAHHHHHHHPPQPPPPPPPPPPHMVHYFHQQP------PTAPQP 190

  Fly   592 PGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQTH 656
            |          |.:  .||...|..||.|.||                |.:........|.
Human   191 P----------PHL--PSQPPQQPPQQSQPQQ----------------PSHPGKMQEAAAV---- 223

  Fly   657 VEGSAASGGGGGGGVGALLALKRNHVMG-GGASQHTLHQQQAVAQQQHSEIIYEELPTDYSGHIE 720
               :||:.......||::..|.:....| |.|:........:.:..:|...|...:..||.|.::
Human   224 ---AAAAAAAAAAAVGSVGRLSQFPPYGLGSAAAAAAAAAASTSGFKHPFAIENIIGRDYKGVLQ 285

  Fly   721 A 721
            |
Human   286 A 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	47/86 (55%)
FOXB2	NP_001013757.1	FH	13..101	CDD:214627	47/88 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..220		23/135 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940