DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxc2

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_998857.1	Gene:	foxc2 / 407875	XenbaseID:	XB-GENE-481382	Length:	463	Species:	Xenopus tropicalis

Alignment Length:	418	Identity:	112/418 - (26%)
Similarity:	159/418 - (38%)	Gaps:	117/418 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 PYLSPTGTISAAN-----SCPASPRQGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNE----- 452
            ||||......||.     :.|.|......|..|....:||              .|:|::
Frog    17 PYLSEQNYYRAAGTYGSMATPMSVYPAHEQYTPGMARSYG--------------PYHHHQPAAPK 67

  Fly   453 ---KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIK 514
               ||||||..||..||..||||::||:|||.||:..:|:|| |..:|||||||||||||..|:|
Frog    68 DLVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYR-ENKQGWQNSIRHNLSLNECFVK 131

  Fly   515 VARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR-------------------SSQGFRPPYGM 560
            |.|...:|||||:|.:||||.....:.|:.:||:|                   ..||..|...:
Frog   132 VPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVSREKEDRILKDQGKVQGPIPSLEL 196

  Fly   561 PR---------SAPVSP--SHMDNSRESSPLQDIVLQSAPGS----PGMSLEQRAADPEIIYNS- 609
            |:         .:|..|  :.::|   .||.....:|.:|.|    |.:|.|....|.....|.
Frog   197 PKHDKKIVIKSESPELPVITKVEN---LSPDGGSAMQDSPRSVASTPSVSTENSIPDQHPASNGF 258

  Fly   610 ---------------------------------QNAHQQQQQQQQQQQQQTLSNNSNQYSS--GS 639
                                             .|..|.|.....|...|::..:.:...|  ..
Frog   259 SVENIMTLRTSPHGDLSPVPAVPCRTGMVPSLPINYTQTQSSVYSQACTQSMDTSGSYQCSMRAM 323

  Fly   640 PYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTL----HQQQAVAQ 700
            ..|..::.|.:..|.|..|.::....|....:.:         |..|:.|.::    |.||....
Frog   324 SLYTGDRPSHMCAPSTLEEATSDHHNGTASPLNS---------MSLGSGQESVLTSSHHQQTATG 379

  Fly   701 QQHSEIIYEELPTD---YSGHIEASEEE 725
            .|.:...|.....|   .|||...|:::
Frog   380 GQTAAPWYLNPGADISHLSGHNFGSQQQ 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	52/86 (60%)
foxc2	NP_998857.1	Forkhead	71..156	CDD:306709	52/85 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920