DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxm1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_957391.1	Gene:	foxm1 / 394072	ZFINID:	ZDB-GENE-040426-1275	Length:	623	Species:	Danio rerio

Alignment Length:	441	Identity:	96/441 - (21%)
Similarity:	152/441 - (34%)	Gaps:	147/441 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 PNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPY 489
            ||..|   .|::|...:.|...:..|:|:|||||..:|..||::..::.:||..||::|..|:||
Zfish   157 PNKDN---PNDSQQQSKGPEKENDPHSERPPYSYMAMIQFAINSKNNRHMTLKEIYNWIEDHFPY 218

  Fly   490 YRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKL-IDHSYK--------- 544
            :|.....||:|||||||||:..||   |.....||.|:|.|.|::...| :|..||
Zfish   219 FRDIAKPGWKNSIRHNLSLHDMFI---RETSPDGKISYWTIRPEANRCLTLDQVYKPLGDPLTPT 280

  Fly   545 -------------KR--------------RQRSSQGFRP-----------PYG----MPRSAPVS 567
                         ||              .:|..:...|           |.|    :|.|:|||
Zfish   281 CPQIPQVAIHQQQKRGAPELKKAIPALGGTERKMKPLLPRTDSYLVPIQLPLGQSLFLPTSSPVS 345

  Fly   568 ---PSHMDNS---------------------------------RESSPLQDIVLQSAPGSPGMSL 596
               |....||                                 :|....|.:....||.......
Zfish   346 LSTPPQTQNSSTPSSSKRVRIAPKVSQSDLSSVLLCKPASQEIKEEPVFQPVTSSEAPPPKSRRT 410

  Fly   597 EQRAA------------DPEIIYNSQNAHQQQ--------QQQQQQQQQQTLSNNSNQYSSGSPY 641
            :..::            :|.::|.........        |..::...:..|.:.:.:||..:|.
Zfish   411 DNSSSRRKQRLVLPATEEPVLLYPDSTLFDSGVISDISTFQDTREADPKPELDSPNREYSFKTPI 475

  Fly   642 YVTNQSSGVAT--PQTHVEGSAASGGGGGG---------GVGALLALKRNHVMGGGASQHTLHQQ 695
            ..::.||...:  |...:|....:..|.||         ..|..:..:||        |||
Zfish   476 KSSHPSSSTPSKLPTVTLEPWRITPVGKGGVLDFSPIRTPTGPHVTPQRN--------QHT---- 528

  Fly   696 QAVAQQQHSEIIYEELPTDYSGHIEASEEECVTTATDATVAKRPKYVSEVL 746
                ....:...::|||      :..|..|.:|.:..:.....|....|:|
Zfish   529 ----SLSFTSTPFKELP------LFNSPRELLTCSRSSPKRSAPACSRELL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	38/87 (44%)
foxm1	NP_957391.1	FH	182..256	CDD:238016	35/76 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820