DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxl1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_957278.1	Gene:	foxl1 / 393959	ZFINID:	ZDB-GENE-040426-1181	Length:	363	Species:	Danio rerio

Alignment Length:	289	Identity:	88/289 - (30%)
Similarity:	126/289 - (43%)	Gaps:	80/289 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 EKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVA 516
            :||||||..||..||..||||:.||||||.||:..:|||. :..:|||||||||||||..||||.
Zfish    51 QKPPYSYIALIAMAIKNAPDKRATLSGIYQFIMDRFPYYH-DNKQGWQNSIRHNLSLNDCFIKVP 114

  Fly   517 RSQDEPGKGSFWRIDPDSGAKLID------HSYKKRRQRSSQGFRPPYGMPRSAPVS-PSHMD-N 573
            |.:..|||||:|.:|    .|.:|      :..:||:.|:........|..|:...| ..|.. .
Zfish   115 REKGRPGKGSYWTLD----TKCLDMFENGNYRRRKRKCRTQDTGDTKVGHKRTRVTSFKLHQGAQ 175

  Fly   574 SRESSPLQDIVLQSAPGSPGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSSG 638
            |.:.|||:.        :||..:::::.|               .|.|.:::...|.::..:...
Zfish   176 SEKVSPLKQ--------NPGRDIKEKSND---------------TQPQNEEENVASESAKDWCLA 217

  Fly   639 SPYYVTN--------QSSGVAT--PQTHVEGSAAS----------GGGGGG-------------- 669
            |...:.:        :||.|:|  ..||...|:||          |....|
Zfish   218 SSTTIVSLPRCTTPERSSTVSTVAVNTHTPLSSASETRVPVKSDTGRAQSGDAKSKESNPRKTTD 282

  Fly   670 -----GVGALLALKRNH-----VMGGGAS 688
                 .:.::|:.|.|.     ...||||
Zfish   283 KAKEFSIDSILSKKENQFQRRCAAAGGAS 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	51/86 (59%)
foxl1	NP_957278.1	FH	52..140	CDD:214627	52/92 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850