DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and Foxc1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_599165.1	Gene:	Foxc1 / 364706	RGDID:	1589718	Length:	553	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	124/466 - (26%)
Similarity:	178/466 - (38%)	Gaps:	149/466 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 SIVVAPPAG-------AAAHLIAGDGPGIYSPLKI-SIPKKEQKSPYLSPTGTISAANSCPASPR 417
            |:.|.|..|       |||....|....:.:|:.: |.|...::.|     |.::.|.. |.:|
  Rat    12 SLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYP-----GGMARAYG-PYTP- 69

  Fly   418 QGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSF 482
                |.||           :|:.            ||||||..||..||..||||::||:|||.|
  Rat    70 ----QPQP-----------KDMV------------KPPYSYIALITMAIQNAPDKKITLNGIYQF 107

  Fly   483 IVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRR 547
            |:..:|:|| :..:|||||||||||||..|:||.|...:|||||:|.:||||.....:.|:.:||
  Rat   108 IMDRFPFYR-DNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRR 171

  Fly   548 QRSS----------------QGFRPPYGMPRSAPVSPSHMDNSR---ESSP--LQDIVLQS---- 587
            :|..                |...||....:.||..|...:.|.   :..|  :|||..::
  Rat   172 RRFKKKDAVKDKEEKGRLHLQEPPPPQAGRQPAPAPPEQAEGSAPGPQQPPVRIQDIKTENGTCP 236

  Fly   588 ------------------------APGSPGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTL 628
                                    :|.|...||...::.|..:.:::.......:.....|....
  Rat   237 SPPQPLSPAAALGSGSAATVPKIESPDSSSSSLSSGSSPPGSLPSARPLSLDAAEPAPPPQPAPP 301

  Fly   629 SNNSNQYS--------SGSPY-------------YVTNQSSGVATP------------------- 653
            .::|..:|        .|||.             ...:..:|:|.|
  Rat   302 PHHSQGFSVDNIMTSLRGSPQGSAAELGSGLLASAAASSRAGIAPPLALGAYSPGHSSLYSSPCS 366

  Fly   654 QTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLHQQ-------------QAVAQQQHSE 705
            |:...||:..|||||||.|...:....   ||.|:.|...|.             |..|....|.
  Rat   367 QSSSAGSSGGGGGGGGGGGGSSSAAGT---GGAATYHCNLQAMSLYAAGERGGHLQGPAGGGGSA 428

  Fly   706 IIYEELPTDYS 716
            .:.:.|| |||
  Rat   429 AVDDPLP-DYS 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	51/86 (59%)
Foxc1	NP_599165.1	FH	78..166	CDD:214627	51/88 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820