DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxK and FOXK2

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_004505.2	Gene:	FOXK2 / 3607	HGNCID:	6036	Length:	660	Species:	Homo sapiens

Alignment Length:	774	Identity:	231/774 - (29%)
Similarity:	302/774 - (39%)	Gaps:	287/774 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 AAATAALNNYNNSSNNNNNSADQLTGNSNNSANHPPATSSTTNSSSSSTTSANTNNPSANAASTL 147
            |||.|||                      :.|..|||........:..
Human     2 AAAAAAL----------------------SGAGTPPAGGGAGGGGAGG----------------- 27

  Fly   148 TSSSPPYG---------ELRFNQEVLPITDAVTVIGRNSSTSLVHFNVAENNLVSRKHFQV---- 199
             ..|||.|         |..:..:...:|     ||||||...|..::..::.:||:|.::
Human    28 -GGSPPGGWAVARLEGREFEYLMKKRSVT-----IGRNSSQGSVDVSMGHSSFISRRHLEIFTPP 86

  Fly   200 -----------LYDVELRA-----FFVQCLSKNGIFVDDFLQRRNVDPLRLPQRCYFRFPSTEIR 248
                       |...:.|.     |:::||.|||:|||...|||...||:||:.|.||||||.|:
Human    87 GGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIK 151

  Fly   249 IEFESYVPATSSDAIDGHSPSLVVGGGGGVAGGGAHVIITPLPRDELHQQQLHHHQQQPHLQQQQ 313
            |.|    .|.||:
Human   152 ITF----TALSSE---------------------------------------------------- 160

  Fly   314 HPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGAAAHLIAGD 378
                      ..::|:..:.|.....||
Human   161 ----------KREKQEASESPVKAVQPH------------------------------------- 178

  Fly   379 GPGIYSPLKISIPKKEQK--SPYLSPTGTISAANSCPASPR----QGFIQNQ--PNNYNNYGNNN 435
                .|||.|:||.....  ||..|||||||||||||:|||    .|:...:  |::.|...:|:
Human   179 ----ISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNS 239

  Fly   436 TQDLFQTPSTA-SYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQ 499
            ..:..:..|.. |...:.||||||||||||||:.||||||||:|||:.|.|:||||| ..:||||
Human   240 QPENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYR-TADKGWQ 303

  Fly   500 NSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYG--MPR 562
            ||||||||||||||||.|||:||||||||||||.|.:|||:.:::|||.|....||.|.|  ..|
Human   304 NSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLIEQAFRKRRPRGVPCFRTPLGPLSSR 368

  Fly   563 SAPVSPSHM--------------DNSRESSP----------------LQDI-VLQSAPGSPGMSL 596
            |||.||:|.              ..|||.||                :|:. ..|||||||
Human   369 SAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEARFAQSAPGSP---- 429

  Fly   597 EQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQT-HV--- 657
              .::.|.:|       ..|:|..|..:..|       |:..:|  ||..:|.....|| ||
Human   430 --LSSQPVLI-------TVQRQLPQAIKPVT-------YTVATP--VTTSTSQPPVVQTVHVVHQ 476

  Fly   658 --EGSAASGGGGGGGVGALLALKRNHVMGGGA---SQHTLHQQQAVAQQ--QHSEIIYEELPTDY 715
              ..|..|..|        ||....:.:.|.|   ....|...:|.||:  .|.|:..:..|...
Human   477 IPAVSVTSVAG--------LAPANTYTVSGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPA 533

  Fly   716 SGH---------IEASEEECVTTATDA-------------TVAKRPKYVSEVLXCVRIQ 752
            .||         |:.::...|.|.|..             ||.:...:|:.|...|..|
Human   534 IGHATLGTASRIIQTAQTTPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVASVPTAVHGQ 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017	38/102 (37%)
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	70/86 (81%)
FOXK2	NP_004505.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		14/73 (19%)
		FHA	47..154	CDD:238017	38/111 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..104		1/18 (6%)
		Required for interaction with DVL2 and SUDS3. /evidence=ECO:0000269\|PubMed:25805136	129..171		20/107 (19%)
		COG5025	<180..577	CDD:227358	166/427 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..260		19/56 (34%)
		Forkhead	257..343	CDD:365978	69/86 (80%)
		DNA-binding, major groove. /evidence=ECO:0000269\|PubMed:16624804	300..318		17/17 (100%)
		DNA-binding, minor groove. /evidence=ECO:0000269\|PubMed:16624804	328..332		3/3 (100%)
		DNA-binding, minor groove. /evidence=ECO:0000269\|PubMed:16624804	348..353		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..407		15/47 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..632
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I4581
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2745
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm40458
orthoMCL	1	0.900	-	-		OOG6_104629
Panther	1	1.100	-	-	O	PTHR45881
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	1	1.000	-	-		X1668
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860