DRSC/TRiP Functional Genomics Resources

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Protein Alignment FoxK and FOXK2

DIOPT Version :10

Sequence 1:NP_001261701.1 Gene:FoxK / 39252 FlyBaseID:FBgn0036134 Length:760 Species:Drosophila melanogaster
Sequence 2:NP_004505.2 Gene:FOXK2 / 3607 HGNCID:6036 Length:660 Species:Homo sapiens


Alignment Length:774 Identity:231/774 - (29%)
Similarity:302/774 - (39%) Gaps:287/774 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 AAATAALNNYNNSSNNNNNSADQLTGNSNNSANHPPATSSTTNSSSSSTTSANTNNPSANAASTL 147
            |||.|||                      :.|..|||........:..                 
Human     2 AAAAAAL----------------------SGAGTPPAGGGAGGGGAGG----------------- 27

  Fly   148 TSSSPPYG---------ELRFNQEVLPITDAVTVIGRNSSTSLVHFNVAENNLVSRKHFQV---- 199
             ..|||.|         |..:..:...:|     ||||||...|..::..::.:||:|.::    
Human    28 -GGSPPGGWAVARLEGREFEYLMKKRSVT-----IGRNSSQGSVDVSMGHSSFISRRHLEIFTPP 86

  Fly   200 -----------LYDVELRA-----FFVQCLSKNGIFVDDFLQRRNVDPLRLPQRCYFRFPSTEIR 248
                       |...:.|.     |:::||.|||:|||...|||...||:||:.|.||||||.|:
Human    87 GGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIK 151

  Fly   249 IEFESYVPATSSDAIDGHSPSLVVGGGGGVAGGGAHVIITPLPRDELHQQQLHHHQQQPHLQQQQ 313
            |.|    .|.||:                                                    
Human   152 ITF----TALSSE---------------------------------------------------- 160

  Fly   314 HPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGAAAHLIAGD 378
                      ..::|:..:.|.....||                                     
Human   161 ----------KREKQEASESPVKAVQPH------------------------------------- 178

  Fly   379 GPGIYSPLKISIPKKEQK--SPYLSPTGTISAANSCPASPR----QGFIQNQ--PNNYNNYGNNN 435
                .|||.|:||.....  ||..|||||||||||||:|||    .|:...:  |::.|...:|:
Human   179 ----ISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNS 239

  Fly   436 TQDLFQTPSTA-SYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQ 499
            ..:..:..|.. |...:.||||||||||||||:.||||||||:|||:.|.|:||||| ..:||||
Human   240 QPENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYR-TADKGWQ 303

  Fly   500 NSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYG--MPR 562
            ||||||||||||||||.|||:||||||||||||.|.:|||:.:::|||.|....||.|.|  ..|
Human   304 NSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLIEQAFRKRRPRGVPCFRTPLGPLSSR 368

  Fly   563 SAPVSPSHM--------------DNSRESSP----------------LQDI-VLQSAPGSPGMSL 596
            |||.||:|.              ..|||.||                :|:. ..|||||||    
Human   369 SAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEARFAQSAPGSP---- 429

  Fly   597 EQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQT-HV--- 657
              .::.|.:|       ..|:|..|..:..|       |:..:|  ||..:|.....|| ||   
Human   430 --LSSQPVLI-------TVQRQLPQAIKPVT-------YTVATP--VTTSTSQPPVVQTVHVVHQ 476

  Fly   658 --EGSAASGGGGGGGVGALLALKRNHVMGGGA---SQHTLHQQQAVAQQ--QHSEIIYEELPTDY 715
              ..|..|..|        ||....:.:.|.|   ....|...:|.||:  .|.|:..:..|...
Human   477 IPAVSVTSVAG--------LAPANTYTVSGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPA 533

  Fly   716 SGH---------IEASEEECVTTATDA-------------TVAKRPKYVSEVLXCVRIQ 752
            .||         |:.::...|.|.|..             ||.:...:|:.|. .|..|
Human   534 IGHATLGTASRIIQTAQTTPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVASVPTAVHGQ 592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxKNP_001261701.1 FHA_FOXK 151..252 CDD:438740 43/129 (33%)
FH_FOXK 453..531 CDD:410800 64/77 (83%)
FOXK2NP_004505.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 14/73 (19%)
FHA_FOXK2 35..157 CDD:438775 40/130 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..104 1/18 (6%)
Required for interaction with DVL2 and SUDS3. /evidence=ECO:0000269|PubMed:25805136 129..171 20/107 (19%)
COG5025 <180..577 CDD:227358 166/427 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..260 19/56 (34%)
FH_FOXK2 256..353 CDD:410829 74/97 (76%)
DNA-binding, major groove. /evidence=ECO:0000269|PubMed:16624804 300..318 17/17 (100%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 328..332 3/3 (100%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 348..353 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..407 15/47 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..632
Blue background indicates that the domain is not in the aligned region.

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