DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and Foxj3

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001101441.1	Gene:	Foxj3 / 313554	RGDID:	1311770	Length:	622	Species:	Rattus norvegicus

Alignment Length:	424	Identity:	113/424 - (26%)
Similarity:	175/424 - (41%)	Gaps:	114/424 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 GIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNNYGNN-NTQDLFQTPS 444
            |:|.....|:......|...|   ::::.:..|....:..||......|.:|.. :.::....|:
  Rat     2 GLYGQACPSVTSLRMTSELES---SLTSMDWLPQLTMRAAIQKSDATQNAHGTGISKKNALLDPN 63

  Fly   445 T------ASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIR 503
            |      ...:.:.|||||||.||..||:::|.|::|||.||.:|..::|||| |...||:||||
  Rat    64 TTLDQEEVQQHKDGKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYR-EAGSGWKNSIR 127

  Fly   504 HNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPR------ 562
            ||||||:.|:||.||:|:|||||:|.||.:.....:. :..|:|.||.:....||.:..
  Rat   128 HNLSLNKCFLKVPRSKDDPGKGSYWAIDTNPKEDTLP-TRPKKRARSVERASTPYSIDSDSLGME 191

  Fly   563 ---SAPVSP-------------------------SHMDNSRESSPLQDIVLQSA----------- 588
               |...||                         |.::||.....|..:.|.|.
  Rat   192 CIISGSASPTLAINTVTNKVTLYNTDQDGSDSPRSSLNNSLSDQSLASVNLNSVGSVHSYTPVTN 256

  Fly   589 ---PGSPGMSLEQR------AADPEIIYNSQN--------------AHQQQQQQQ------QQQQ 624
               |.|..::.:|:      ..|.::::...|              ..:|...||      .:..
  Rat   257 HPEPVSQSLTPQQQPQYNLPERDKQLLFTEYNFEDLSASFRSLYKSVFEQSLSQQGLMSIPSESS 321

  Fly   625 QQTLSNNSNQYSSGS-----PYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNHVMG 684
            ||:.::.|.|:|..|     |:  :||||   .|..| .|.:|:|......|.  |:..:.|..
  Rat   322 QQSHTSCSYQHSPSSTVTSHPH--SNQSS---LPNNH-SGLSATGSNSVAQVS--LSHPQMHTQ- 377

  Fly   685 GGASQHTLHQQQAVAQ------------QQHSEI 706
              .|.||.|:...:.|            ||||::
  Rat   378 --PSPHTPHRPHGLPQHPQRPQHPASHPQQHSQL 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	50/86 (58%)
Foxj3	NP_001101441.1	COG5025	<54..345	CDD:227358	82/294 (28%)
Foxj3	NP_001101441.1	FH_FOXJ3	77..155	CDD:410826	48/78 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920