DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxd5

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_571345.1	Gene:	foxd5 / 30524	ZFINID:	ZDB-GENE-980605-4	Length:	321	Species:	Danio rerio

Alignment Length:	282	Identity:	79/282 - (28%)
Similarity:	123/282 - (43%)	Gaps:	36/282 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 QKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNNYGNNNT----QDLFQTPSTASYNHNEKPP 455
            |::|.......|.......:...:.:....|...::.|:.::    .|...:......:.:.|||
Zfish    11 QRTPISPEDDEIDIVGGDHSDSEREYFMRDPTEVDHSGSESSGESESDFASSTVAPKQSSSVKPP 75

  Fly   456 YSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQD 520
            |||..||..||..:|.|:||||||..||...:||| ||....||||||||||||..|||:.|...
Zfish    76 YSYIALITMAILQSPMKKLTLSGICDFISNKFPYY-KEKFPAWQNSIRHNLSLNDCFIKIPREPG 139

  Fly   521 EPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQG-----------FRP-----PYGMPRSAPVSPS 569
            .||||::|.:||.|.....:.|:.:||:|..:.           :.|     .||.|.....:..
Zfish   140 NPGKGNYWSLDPASEDMFDNGSFLRRRKRFKRNQPEFTKDSLVLYHPTLSYRAYGRPYCVSGAVP 204

  Fly   570 HMDNSRESSPLQDIVLQSAPGSPGMSLEQRAAD-PEIIYNSQNAHQQQQQQQQQQQ-----QQTL 628
            ...|.....|:.|.::...|.....::..:..| |||         ||:.:.:.|:     ...:
Zfish   205 AQTNPVGYLPVPDGIMVPPPFFQYQTMNIKIHDAPEI---------QQRPEHKTQRCSFSIDSIM 260

  Fly   629 SNNSNQYSSGSPYYVTNQSSGV 650
            :.::...|..|.:::|...|.|
Zfish   261 AKSTESSSKSSAHHLTPDYSFV 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	49/86 (57%)
foxd5	NP_571345.1	Forkhead	73..159	CDD:278670	49/86 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850