DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxK and Foxk1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001032296.2	Gene:	Foxk1 / 304298	RGDID:	1309643	Length:	719	Species:	Rattus norvegicus

Alignment Length:	614	Identity:	212/614 - (34%)
Similarity:	274/614 - (44%)	Gaps:	214/614 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PATSSTTNSSSSSTTSANTNNPSANAASTLTSSSPPYGELRFNQ-EVLPITDAVTVIGRNSSTSL 181
            |:|::|..:::.:..       :|.|||...|..|....|...: |.|....:|| ||||||...
  Rat    63 PSTAATATATAPALV-------AAAAASVRQSPGPALARLEGREFEFLMRQPSVT-IGRNSSQGS 119

  Fly   182 VHFNVAENNLVSRKHFQVLYDVELRAFFVQCLSKNGIFVDDFLQRRNVDPLRLPQRCYFRFPSTE 246
            |..|:..::.:||:|.|:.:  :...|:::||.|||:|||...|||....|:|||:|.||||||.
  Rat   120 VDLNMGLSSFISRRHLQLSF--QEPHFYLRCLGKNGVFVDGAFQRRGAPALQLPQQCTFRFPSTA 182

  Fly   247 IRIEFESYVPATSSDAIDGHSPSLVVGGGGGVAGGGAHVIITPLPRDELHQQQLHHHQQQPHLQQ 311
            |:|:|.|                                              |:|.::
  Rat   183 IKIQFTS----------------------------------------------LYHKEE------ 195

  Fly   312 QQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGAAAHLIA 376
                                       .|.:|..||:
  Rat   196 ---------------------------APASPLRPLY---------------------------- 205

  Fly   377 GDGPGIYSPLKISIPKKEQK---SPYLSPTGTISAANSCPASPRQG------FIQNQPNNYNNYG 432
               |.| |||||.||:.:.:   ||..|||||||..||||||||..      |:||.
  Rat   206 ---PQI-SPLKIHIPEPDLRSLVSPIPSPTGTISVPNSCPASPRGAGSSSYRFVQNV-------- 258

  Fly   433 NNNTQDL---------------FQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSF 482
               |.||               ..|....|.....|||||||||||||||:|.|:||||||||:.
  Rat   259 ---TSDLQLAAEFAAKAASEQQADTSGGDSPKDESKPPYSYAQLIVQAISSAQDRQLTLSGIYAH 320

  Fly   483 IVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRR 547
            |.||||||| ..:||||||||||||||||||||.|||:||||||||||||.|.|||::.:::|||
  Rat   321 ITKHYPYYR-TADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASEAKLVEQAFRKRR 384

  Fly   548 QRSSQGFRPPYG--MPRSAPVSPSHMD--------------NSRESSPL---QDI---------- 583
            ||....||.|:|  ..||||.||:|..              .|||.||:   .|:
  Rat   385 QRGVSCFRTPFGPLSSRSAPASPTHPGLMSPRSSGLQTPECLSREGSPIPHDPDLGSKLASVPEY 449

  Fly   584 -VLQSAPGSPG------MSLEQRAAD---------PEIIYNSQ--NAH-----QQQQQQQQQQQQ 625
             ..|||||||.      |::..|.::         |..|..||  :.|     ||.......:..
  Rat   450 RYSQSAPGSPVSAQPVIMAVPPRPSNLVAKPVAYMPASIVTSQQPSGHAIHVVQQAPTVTMVRVV 514

  Fly   626 QTLSNNSNQY---SSGSPYYVTNQSSGVA 651
            .|.:|::|.|   |.||. ..::.::|.|
  Rat   515 TTSANSANGYILASQGST-ATSHDTAGTA 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017	40/82 (49%)
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	72/86 (84%)
Foxk1	NP_001032296.2	FHA	<88..190	CDD:224630	45/150 (30%)
		FHA	96..189	CDD:238017	42/95 (44%)
		Forkhead	291..377	CDD:278670	72/86 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	147	1.000	Domainoid score	I4390
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2648
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm44601
orthoMCL	1	0.900	-	-		OOG6_104629
Panther	1	1.100	-	-	LDO	PTHR45881
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1668
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830