DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FoxK and FOXB1

DIOPT Version :9

Sequence 1:NP_001261701.1 Gene:FoxK / 39252 FlyBaseID:FBgn0036134 Length:760 Species:Drosophila melanogaster
Sequence 2:NP_036314.2 Gene:FOXB1 / 27023 HGNCID:3799 Length:325 Species:Homo sapiens


Alignment Length:253 Identity:83/253 - (32%)
Similarity:120/253 - (47%) Gaps:37/253 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   443 PSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLS 507
            |...:|: ::||||||..|...||.::|:|.|.||.||.||:..:||||:.|.: ||||:|||||
Human     4 PGRNTYS-DQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQR-WQNSLRHNLS 66

  Fly   508 LNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPRSAPVSPSHMD 572
            .|..|||:.|..|:|||||||.:.|..|....:.|:.:||:|        :.:.:|..::||...
Human    67 FNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSFLRRRKR--------FKVLKSDHLAPSKPA 123

  Fly   573 NSRESSPLQDIVLQSAPGSPGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQ--- 634
            ::.:....|..:..||..:.|..|.|.   |...||.....|....:.....:..::.....   
Human   124 DAAQYLQQQAKLRLSALAASGTHLPQM---PAAAYNLGGVAQPSGFKHPFAIENIIAREYKMPGG 185

  Fly   635 --YSSGSP----YYVTNQ----SSGVATPQTHVEGSA-----------ASGGGGGGGV 671
              :|:..|    |.:.||    .|.:.|...||.|||           |||.....||
Human   186 LAFSAMQPVPAAYPLPNQLTTMGSSLGTGWPHVYGSAGMIDSATPISMASGDYSAYGV 243

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxKNP_001261701.1 FHA <170..253 CDD:238017
Forkhead 453..540 CDD:278670 47/86 (55%)
FOXB1NP_036314.2 FH_FOXB2 1..110 CDD:410817 53/115 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 284..325
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2114
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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