DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxK and fkh2

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_596764.1	Gene:	fkh2 / 2539703	PomBaseID:	SPBC16G5.15c	Length:	642	Species:	Schizosaccharomyces pombe

Alignment Length:	611	Identity:	138/611 - (22%)
Similarity:	204/611 - (33%)	Gaps:	238/611 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 GRNSSTSLVHFNVAENNLVSRKHFQVLYDVELRAFFVQCLSKNGIFVDDFLQRRNVDPLRLPQRC 238
            |:|....::..|...:.:|||||..|.||::.:.:......:|||.||..|.:
pombe   109 GKNEDLEVIDMNFGPSKVVSRKHAVVEYDLDDQTWNCSVYGRNGIKVDGKLFK------------ 161

  Fly   239 YFRFPSTEIRIEFESYVPATSSDAIDGHSPSLVVGGGGGVAGGGAHVIITPLPRDELHQQQLHHH 303
                                     :|.:..|..|....|||
pombe   162 -------------------------NGETVKLTSGSILEVAG----------------------- 178

  Fly   304 QQQPHLQQQQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPA 368
                 ||..        ..||...:|:|...
pombe   179 -----LQMM--------FVLPNAAEQKQTDE---------------------------------- 196

  Fly   369 GAAAHLIAGDGPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNNYGN 433
                           |.:|....|.|           ||||
pombe   197 ---------------STIKEDAIKSE-----------ISAA------------------------ 211

  Fly   434 NNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGW 498
                    ....|.|..|:||||||:.:|.|||.::.:..:|||.|||:|..|||||| .|..||
pombe   212 --------VNDAAEYGDNKKPPYSYSVMIAQAILSSSECMMTLSNIYSWISTHYPYYR-TTKSGW 267

  Fly   499 QNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPRS 563
            |||||||||||:.|.||.|...|.|||..|.|.|:...:.|..:.|..|:||.           |
pombe   268 QNSIRHNLSLNKAFRKVPRKSGEQGKGMKWSIVPEFREEFIAKTRKTPRKRSP-----------S 321

  Fly   564 APVSPSHMDNSRESSP---------LQDIVLQSA-PGSPGMSL-EQRAADPEIIYNSQNAHQQQQ 617
            :||  ..:...||.||         ::|..:.:| |.|...|. :|..:.|:.:.:...|....:
pombe   322 SPV--PLLAKKREGSPSLPIPILPKMKDTSIPAAEPASSTTSARDQTPSTPKDVGSPSTAETSAE 384

  Fly   618 QQQQQQQQQTL----------------SNNSNQYSS-------GSPYYVTNQSSG----VATPQT 655
            ::|.:..:...                :|:::|...       ||..|.|:..:.    ||.|..
pombe   385 EKQMETYKTPTHAALSDIISTHDYALDANSASQTKKAAFGSPIGSSTYPTSSPAPFWKYVAVPNP 449

  Fly   656 HVEGSAASGGGGGGGVGA--LLALKRNHVMGGGASQHTLHQQQAVAQQQHSEIIYEELPTDYSGH 718
            |          ....||:  .::..||.|     :.|.::.|   .||...:.|.|:| .|..|.
pombe   450 H----------DWPQVGSYDTISPYRNPV-----NSHLIYSQ---IQQSSPKKIDEQL-HDLQGV 495

  Fly   719 IEASEEECVTTATDATVAKRPKYVSE 744
            ...:..|.:::..::.|.|....||:
pombe   496 DLVNGFEGISSWRESMVNKLRSSVSD 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017	17/78 (22%)
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	48/86 (56%)
fkh2	NP_596764.1	COG5025	6..622	CDD:227358	138/611 (23%)
		FHA	81..185	CDD:238017	25/148 (17%)
		Forkhead	223..308	CDD:278670	48/85 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	104	1.000	Domainoid score	I1720
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104629
Panther	1	1.100	-	-	LDO	PTHR45881
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	1	1.000	-	-		X1668
TreeFam	0	0.000	Not matched by this tool.
	7	6.930