DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxK and Foxj3

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001344106.1	Gene:	Foxj3 / 230700	MGIID:	2443432	Length:	623	Species:	Mus musculus

Alignment Length:	423	Identity:	115/423 - (27%)
Similarity:	169/423 - (39%)	Gaps:	110/423 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 GIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNNYGNN-NTQDLFQTPS 444
            |:|.....|:......|...|   ::::.:..|....:..||......|.:|.. :.::....|:
Mouse     2 GLYGQACPSVTSLRMTSELES---SLTSMDWLPQLTMRAAIQKSDATQNAHGTGISKKNALLDPN 63

  Fly   445 T------ASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIR 503
            |      ...:.:.|||||||.||..||:::|.|::|||.||.:|..::|||| |...||:||||
Mouse    64 TTLDQEEVQQHKDGKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYR-EAGSGWKNSIR 127

  Fly   504 HNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPR------ 562
            ||||||:.|:||.||:|:|||||:|.||.:.....:. :..|:|.||.:....||.:..
Mouse   128 HNLSLNKCFLKVPRSKDDPGKGSYWAIDTNPKEDTLP-TRPKKRARSVERASTPYSIDSDSLGME 191

  Fly   563 ---SAPVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAAD---------------------- 602
               |...||:...|:..:........|....||..||....:|
Mouse   192 CIISGSASPTLAINTVTNKVTLYNADQDGSDSPRSSLNNSLSDQSLASVNLNSVGSVHSYTPVTN 256

  Fly   603 -PEIIYNSQNAHQQQQQQQQ-------------------------------------QQQQQTLS 629
             ||.:  ||....|||||.|                                     ||...::.
Mouse   257 HPEPV--SQPLTPQQQQQPQYNLPEREKQLLFTEYNFEDLSASFRSLYKSVFEQSLSQQGLMSIP 319

  Fly   630 NNSNQYSSGSPYYVTNQSSGVAT---------PQTHVEGSAASGGGGGGGVGALLALKRNHVMGG 685
            :.|:|.|..|..|..:.||.|.:         |..| .|.:|:|......|.  |:..:.|..
Mouse   320 SESSQQSHTSCSYQHSPSSTVTSHPHSNQSSLPNNH-SGLSATGSNSVAQVS--LSHPQMHPQ-- 379

  Fly   686 GASQHTLHQQQAVAQ------------QQHSEI 706
             .|.||.|:...:.|            ||||::
Mouse   380 -PSPHTPHRPHGLPQHPQRPQHPAPHPQQHSQL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	50/86 (58%)
Foxj3	NP_001344106.1	COG5025	<54..347	CDD:227358	88/296 (30%)
		Forkhead	78..155	CDD:365978	48/77 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..178		13/35 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..275		9/28 (32%)
		PAT1	<311..>434	CDD:370676	27/107 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..451		25/102 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820