DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and FOXS1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_004109.1	Gene:	FOXS1 / 2307	HGNCID:	3735	Length:	330	Species:	Homo sapiens

Alignment Length:	156	Identity:	60/156 - (38%)
Similarity:	83/156 - (53%)	Gaps:	23/156 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVAR 517
            ||||||..||..||.::|.::.||||||.:|:..:.:|| ....|||||||||||||..|:||.|
Human    18 KPPYSYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYR-HNRPGWQNSIRHNLSLNECFVKVPR 81

  Fly   518 SQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR-----SSQGFRPPYGMPRSAPVSPSHMDNSRES 577
            ...:|||||:|.:|||........|:.:||:|     .::|.|.| ...|..|:..:..|
Human    82 DDRKPGKGSYWTLDPDCHDMFEHGSFLRRRRRFTRQTGAEGTRGP-AKARRGPLRATSQD----- 140

  Fly   578 SPLQDIVLQSAPGSPGMSLEQRAADP 603
                       ||.|..:..::.:.|
Human   141 -----------PGVPNATTGRQCSFP 155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	46/86 (53%)
FOXS1	NP_004109.1	Forkhead	18..103	CDD:306709	46/85 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..157		12/62 (19%)
		DNA_pol3_gamma3	<116..313	CDD:331207	10/57 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..200
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820