DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxK and FOXE1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_004464.2	Gene:	FOXE1 / 2304	HGNCID:	3806	Length:	373	Species:	Homo sapiens

Alignment Length:	337	Identity:	89/337 - (26%)
Similarity:	121/337 - (35%)	Gaps:	118/337 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVAR 517
            ||||||..||..||:.||:::|||.|||.||.:.:|:|| :..|.|||||||||:||..|:|:.|
Human    53 KPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYR-DNPKKWQNSIRHNLTLNDCFLKIPR 116

  Fly   518 SQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQ------------------------------ 552
            ....||||::|.:||::.......|:.:||:|..:
Human   117 EAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIF 181

  Fly   553 -----------------GFRPP--------------------YGMPRSAPVSPSHMDNSRESSPL 580
                             |:.||                    :|:....|:||.
Human   182 PGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPE----------- 235

  Fly   581 QDIVLQSAPGSPGMSLE-QRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPY--- 641
                |..||..||.|.. ..|..|......|.|            ..|.:..:|..:..:.|
Human   236 ----LGPAPSGPGGSCAFASAGAPATTTGYQPA------------GCTGARPANPSAYAAAYAGP 284

  Fly   642 ---YVTNQSSGVATPQTHVEGSAA-SGGGGGGGV---------------GALLALKRNHVMGGGA 687
               |.....|.:......:.|.|: ..||..|||               |||.|........|||
Human   285 DGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGA 349

  Fly   688 SQHTLHQQQAVA 699
            |....|.:.|.|
Human   350 SAGAYHARHAAA 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	45/86 (52%)
FOXE1	NP_004464.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..51
FOXE1	NP_004464.2	FH	53..141	CDD:214627	45/88 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820