DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxK and FOXJ1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001445.2	Gene:	FOXJ1 / 2302	HGNCID:	3816	Length:	421	Species:	Homo sapiens

Alignment Length:	421	Identity:	113/421 - (26%)
Similarity:	171/421 - (40%)	Gaps:	115/421 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 PPAGA---AAHLIAGD-GPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPN 426
            ||.|.   ..|.:.|. .||  |||........|......||.:.::.::.|.      :|..|
Human    53 PPGGTDPHGYHQVPGSAAPG--SPLAADPACLGQPHTPGKPTSSCTSRSAPPG------LQAPP- 108

  Fly   427 NYNNYGNNNTQDLFQTPSTASY--NHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPY 489
                            |....|  |.:.|||||||.||..|:.|:...::|||.||.:|..::.|
Human   109 ----------------PDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCY 157

  Fly   490 YRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRR------- 547
            :| ..:..||||||||||||:.||||.|.:||||||.||||||....:|:..::||||
Human   158 FR-HADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIH 221

  Fly   548 -QRSSQGFRPPYGMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAADPEIIYNSQN 611
             ..:.|..:.|..:||:.|::.    |:.....|::  .:.|.|..|....:          .:.
Human   222 PAFARQAAQEPSAVPRAGPLTV----NTEAQQLLRE--FEEATGEAGWGAGE----------GRL 270

  Fly   612 AHQQQQQQQQQ-----QQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQTHVEGSAASG------- 664
            .|:::|...::     :...||                     :.||:...|.....|
Human   271 GHKRKQPLPKRVAKVPRPPSTL---------------------LPTPEEQGELEPLKGNFDWEAI 314

  Fly   665 ---GGGGGGVGALLALKRNHVMGGGASQH-----TLHQQQ--------AVAQQQHSEIIYEE--L 711
               |..||.:|||.||:.:..:  ..:.|     |:|.:.        ...:|....:.::|  |
Human   315 FDAGTLGGELGALEALELSPPL--SPASHVDVDLTIHGRHIDCPATWGPSVEQAADSLDFDETFL 377

  Fly   712 PTDYSGH-IEASEEECVT-----TATDATVA 736
            .|.:..| .:.|...|:.     .|.|||:|
Human   378 ATSFLQHPWDESGSGCLPPEPLFEAGDATLA 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	49/86 (57%)
FOXJ1	NP_001445.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..116		18/87 (21%)
		Forkhead	121..205	CDD:306709	48/84 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..302		7/71 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850