DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and FOXI1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_036320.2	Gene:	FOXI1 / 2299	HGNCID:	3815	Length:	378	Species:	Homo sapiens

Alignment Length:	368	Identity:	109/368 - (29%)
Similarity:	168/368 - (45%)	Gaps:	64/368 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 GIYSPLKISIPKKEQ----KSPYL---SPTGT----ISAANSCPASPRQGFIQNQP--NNYNNYG 432
            |:.||.:.|.....:    .:|||   .||.|    :...|:.|..| |.:...:|  .:.:..|
Human    40 GVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLP-QAYGVQRPLLPSVSGLG 103

  Fly   433 NNNTQDL--FQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETN 495
            .:   ||  ...||........:|||||:.||..||..||||:||||.||.::..::|:|.| :.
Human   104 GS---DLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNK-SK 164

  Fly   496 KGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDH-SYKKRRQRSSQGFRPPYG 559
            .|||||||||||||..|.||.|.:|:||||::|.:||:. .|:.|: :::::|:|.|........
Human   165 AGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNC-EKMFDNGNFRRKRKRKSDVSSSTAS 228

  Fly   560 MPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAADPE----------------IIYN 608
            :......|...:|:.:.:.| |||:..::||....|.|:|.:.|.                :...
Human   229 LALEKTESSLPVDSPKTTEP-QDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGG 292

  Fly   609 SQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGA 673
            |..:|.........:.......||..::|.||  :||.|:       |      ||||....
Human   293 SPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSP--LTNLSN-------H------SGGGDWAN--- 339

  Fly   674 LLALKRNHVMGGGA--SQHTLHQQQAVAQQQHSEIIYEELPTD 714
              .:..|.:..||:  ||.:.|...:|   ..|.::|....|:
Human   340 --PMPTNMLSYGGSVLSQFSPHFYNSV---NTSGVLYPREGTE 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	48/86 (56%)
FOXI1	NP_036320.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		FH	123..211	CDD:214627	49/89 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..278		16/70 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820