DRSC/TRiP Functional Genomics Resources

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Protein Alignment FoxK and FOXC1

DIOPT Version :10

Sequence 1:NP_001261701.1 Gene:FoxK / 39252 FlyBaseID:FBgn0036134 Length:760 Species:Drosophila melanogaster
Sequence 2:NP_001444.2 Gene:FOXC1 / 2296 HGNCID:3800 Length:553 Species:Homo sapiens


Alignment Length:489 Identity:130/489 - (26%)
Similarity:178/489 - (36%) Gaps:192/489 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   361 SIVVAPPAG-------AAAHLIAGDGPGIYSPLKI-SIPKKEQKSPYLSPTGTISAANSCPASPR 417
            |:.|.|..|       |||....|....:.:|:.: |.|...::.|     |.::.|.. |.:| 
Human    12 SLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYP-----GGMARAYG-PYTP- 69

  Fly   418 QGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSF 482
                |.||           :|:.            ||||||..||..||..||||::||:|||.|
Human    70 ----QPQP-----------KDMV------------KPPYSYIALITMAIQNAPDKKITLNGIYQF 107

  Fly   483 IVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRR 547
            |:..:|:|| :..:|||||||||||||..|:||.|...:|||||:|.:||||.....:.|:.:||
Human   108 IMDRFPFYR-DNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRR 171

  Fly   548 QRSSQGFR-------------------PPYGMPRSAPVSPSHMDNSRESSP------LQDIVLQS 587
            :|    |:                   ||.|  |..|.:|....:.....|      :|||..::
Human   172 RR----FKKKDAVKDKEEKDRLHLKEPPPPG--RQPPPAPPEQADGNAPGPQPPPVRIQDIKTEN 230

  Fly   588 A-------PGSPGMSL--EQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSS------ 637
            .       |.||..:|  ...||.|:|             :.......:||:.|:...|      
Human   231 GTCPSPPQPLSPAAALGSGSAAAVPKI-------------ESPDSSSSSLSSGSSPPGSLPSARP 282

  Fly   638 ------------------------------------GSPY------------------------- 641
                                                |||.                         
Human   283 LSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTSLRGSPQSAAAELSSGLLASAAASSRAGIAPP 347

  Fly   642 -----YVTNQSSGVATP--QTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLH-QQQAV 698
                 |...|||..::|  ||   .||.|.||||||.||         .||.....|.| ..||:
Human   348 LALGAYSPGQSSLYSSPCSQT---SSAGSSGGGGGGAGA---------AGGAGGAGTYHCNLQAM 400

  Fly   699 AQQQHSEIIYEELPTDYSGHIEASEEECVTTATD 732
            :.....|         ..||::.:......:|.|
Human   401 SLYAAGE---------RGGHLQGAPGGAGGSAVD 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxKNP_001261701.1 FHA_FOXK 151..252 CDD:438740
FH_FOXK 453..531 CDD:410800 47/77 (61%)
FOXC1NP_001444.2 Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 1..51 10/38 (26%)
FH_FOXC1 73..165 CDD:410818 53/115 (46%)
Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000269|PubMed:11782474 78..93 10/14 (71%)
Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000269|PubMed:11782474 168..176 4/11 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..310 24/155 (15%)
Required for transcriptional inhibition. /evidence=ECO:0000269|PubMed:11782474 215..366 24/163 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..387 18/42 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..465 2/12 (17%)
Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 466..553
Blue background indicates that the domain is not in the aligned region.

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