DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxK and FOXG1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_005240.3	Gene:	FOXG1 / 2290	HGNCID:	3811	Length:	489	Species:	Homo sapiens

Alignment Length:	390	Identity:	119/390 - (30%)
Similarity:	167/390 - (42%)	Gaps:	57/390 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 DELHQQQLHH--HQQQPHLQQQQHPHH--PPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALH 353
            |..|....||  |..|.|.....|.||  |||...|...||||..|   |.|..|..|....|..
Human    31 DNHHASHGHHNSHHPQHHHHHHHHHHHPPPPAPQPPPPPQQQQPPP---PPPPAPQPPQTRGAPA 92

  Fly   354 QQQQRSGSIVVAPPA----------GAAAHLIA-----GDGPGIYSPLKISIPKKEQKSPYLSPT 403
            ....:....::.||.          ||.|..:.     |.|||..:|:.   |.:::|.......
Human    93 ADDDKGPQQLLLPPPPPPPPAAALDGAKADGLGGKGEPGGGPGELAPVG---PDEKEKGAGAGGE 154

  Fly   404 GTISAANSCPASPRQGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISA 468
            ....|...  ....:|..:.:..|                  ..|   ||||:||..||:.||..
Human   155 EKKGAGEG--GKDGEGGKEGEKKN------------------GKY---EKPPFSYNALIMMAIRQ 196

  Fly   469 APDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPD 533
            :|:|:|||:|||.||:|::|||| |..:|||||||||||||:.|:||.|..|:||||::|.:||.
Human   197 SPEKRLTLNGIYEFIMKNFPYYR-ENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPS 260

  Fly   534 SGAKLIDHSYKKRRQRSSQGFRPPYGMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQ 598
            |....|..:..|.|:||:.. |......|.|.::.:.:.....:..|.      .|.||.:||..
Human   261 SDDVFIGGTTGKLRRRSTTS-RAKLAFKRGARLTSTGLTFMDRAGSLY------WPMSPFLSLHH 318

  Fly   599 RAADPEIIYN-SQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQTHVEGSAA 662
            ..|...:.|| :.:|:............|....|::.:|:.:...|....:|.....||...:||
Human   319 PRASSTLSYNGTTSAYPSHPMPYSSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAA 383

Fly 663 662
Human 384 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	51/86 (59%)
FOXG1	NP_005240.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..181		40/178 (22%)
		FH_FOXG	181..259	CDD:410795	48/78 (62%)
		COG5025	<184..>356	CDD:227358	68/179 (38%)
		Required for interaction with TLE6. /evidence=ECO:0000250\|UniProtKB:Q60987	249..344		26/101 (26%)
		Interaction with KDM5B. /evidence=ECO:0000269\|PubMed:12657635	383..406		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..455
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850