DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and FOXJ3

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_005270689.1	Gene:	FOXJ3 / 22887	HGNCID:	29178	Length:	630	Species:	Homo sapiens

Alignment Length:	418	Identity:	114/418 - (27%)
Similarity:	176/418 - (42%)	Gaps:	102/418 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 LKISIPKKEQKSPYLSPTGT------ISAANSCPASPRQGFIQNQPNNYNNYGNN-NTQDLFQTP 443
            |.|:||:.::.|.|.....|      :::.:..|....:..||......|.:|.. :.::....|
Human     6 LWINIPENQEDSIYWQCRMTSELESSLTSMDWLPQLTMRAAIQKSDATQNAHGTGISKKNALLDP 70

  Fly   444 ST------ASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSI 502
            :|      ...:.:.|||||||.||..||:::|.|::|||.||.:|..::|||| |...||:|||
Human    71 NTTLDQEEVQQHKDGKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYR-EAGSGWKNSI 134

  Fly   503 RHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPR----- 562
            |||||||:.|:||.||:|:|||||:|.||.:....::. :..|:|.||.:....||.:..
Human   135 RHNLSLNKCFLKVPRSKDDPGKGSYWAIDTNPKEDVLP-TRPKKRARSVERASTPYSIDSDSLGM 198

  Fly   563 ----SAPVSP-------------------------SHMDNSRESSPLQDIVLQSA---------- 588
                |...||                         |.::||.....|..:.|.|.
Human   199 ECIISGSASPTLAINTVTNKVTLYNTDQDGSDSPRSSLNNSLSDQSLASVNLNSVGSVHSYTPVT 263

  Fly   589 --PGS----------PGMSLEQRAADPEIIYNSQNAHQQQ-----------QQQQQQQQQQTLSN 630
              |.|          |..:|.:|  |.:::::..|.....           :|...||....:.:
Human   264 SHPESVSQSLTPQQQPQYNLPER--DKQLLFSEYNFEDLSASFRSLYKSVFEQSLSQQGLMNIPS 326

  Fly   631 NSNQYSSGSPYYVTNQSSGVATPQTHVEGSAASGGGGGG----GVGALLALKRNH-VMGGGASQH 690
            .|:|.|..|..|..:.||.|:| ..|...|:.|...|.|    |..::..:..:| .|....|.|
Human   327 ESSQQSHTSCTYQHSPSSTVST-HPHSNQSSLSNSHGSGLNTTGSNSVAQVSLSHPQMHTQPSPH 390

  Fly   691 TLHQQQAVAQ------------QQHSEI 706
            ..|:...:.|            ||||::
Human   391 PPHRPHGLPQHPQRSPHPAPHPQQHSQL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	50/86 (58%)
FOXJ3	XP_005270689.1	Forkhead	86..163	CDD:278670	48/77 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820