DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FoxK and Foxk1

DIOPT Version :10

Sequence 1:NP_001261701.1 Gene:FoxK / 39252 FlyBaseID:FBgn0036134 Length:760 Species:Drosophila melanogaster
Sequence 2:NP_951031.2 Gene:Foxk1 / 17425 MGIID:1347488 Length:719 Species:Mus musculus


Alignment Length:633 Identity:219/633 - (34%)
Similarity:277/633 - (43%) Gaps:215/633 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 PPATSSTTNSS--SSSTTSANTNNP---SANAASTLTSSSPPYGELRFNQ-EVLPITDAVTVIGR 175
            |||..:.....  .|:..:|.|..|   :|.|||...|..|....|...: |.|....:|| |||
Mouse    50 PPALPAEPGPGPVPSTVATATTTAPALVAAAAASVRQSPGPALARLEGREFEFLMRQPSVT-IGR 113

  Fly   176 NSSTSLVHFNVAENNLVSRKHFQVLYDVELRAFFVQCLSKNGIFVDDFLQRRNVDPLRLPQRCYF 240
            |||...|..::..::.:||:|.|:.:  :...|:::||.|||:|||...|||....|:|||:|.|
Mouse   114 NSSQGSVDLSMGLSSFISRRHLQLSF--QEPHFYLRCLGKNGVFVDGAFQRRGAPALQLPQQCTF 176

  Fly   241 RFPSTEIRIEFESYVPATSSDAIDGHSPSLVVGGGGGVAGGGAHVIITPLPRDELHQQQLHHHQQ 305
            |||||.|:|:|.|                                              |:|.::
Mouse   177 RFPSTAIKIQFTS----------------------------------------------LYHKEE 195

  Fly   306 QPHLQQQQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGA 370
                                             .|.:|..||:                      
Mouse   196 ---------------------------------APASPLRPLY---------------------- 205

  Fly   371 AAHLIAGDGPGIYSPLKISIPKKEQK---SPYLSPTGTISAANSCPASPRQG------FIQNQPN 426
                     |.| |||||.||:.:.:   ||..|||||||..||||||||..      |:||.  
Mouse   206 ---------PQI-SPLKIHIPEPDLRSLVSPIPSPTGTISVPNSCPASPRGAGSSSYRFVQNV-- 258

  Fly   427 NYNNYGNNNTQDLFQTPSTASYNHNE---------------KPPYSYAQLIVQAISAAPDKQLTL 476
                     |.||......|:...:|               |||||||||||||||:|.|:||||
Mouse   259 ---------TSDLQLAAEFAAKAASEQQADASGGDSPKDESKPPYSYAQLIVQAISSAQDRQLTL 314

  Fly   477 SGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDH 541
            ||||:.|.||||||| ..:||||||||||||||||||||.|||:||||||||||||.|.|||::.
Mouse   315 SGIYAHITKHYPYYR-TADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASEAKLVEQ 378

  Fly   542 SYKKRRQRSSQGFRPPYG--MPRSAPVSPSHMD--------------NSRESSPL---QDI---- 583
            :::|||||....||.|:|  ..||||.||:|..              .|||.||:   .|:    
Mouse   379 AFRKRRQRGVSCFRTPFGPLSSRSAPASPTHPGLMSPRSSGLQTPECLSREGSPIPHDPDLGSKL 443

  Fly   584 -------VLQSAPGSPG------MSLEQRAAD---------PEIIYNSQ--NAH-----QQQQQQ 619
                   ..|||||||.      |::..|.::         |..|..||  :.|     ||....
Mouse   444 ASVPEYRYSQSAPGSPVSAQPVIMAVPPRPSNLVAKPVAYMPASIVTSQQPSGHAIHVVQQAPTV 508

  Fly   620 QQQQQQQTLSNNSNQY---SSGSPYYVTNQSSGVATPQTHVEGSAASG 664
            ...:...|.:|::|.|   |.||    |..|...|.......|:.|.|
Mouse   509 TMVRVVTTSANSANGYILASQGS----TGTSHDTAGTAVLDLGNEARG 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxKNP_001261701.1 FHA_FOXK 151..252 CDD:438740 42/101 (42%)
FH_FOXK 453..531 CDD:410800 65/77 (84%)
Foxk1NP_951031.2 Interaction with SIN3A and SIN3B. /evidence=ECO:0000269|PubMed:10620510, ECO:0000269|PubMed:22476904 2..40
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..67 4/16 (25%)
Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000269|PubMed:22956541 81..406 173/450 (38%)
FHA 89..191 CDD:469597 44/150 (29%)
FH_FOXK1 289..389 CDD:410828 77/100 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..443 13/43 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..719
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.