DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and let-381

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_491826.1	Gene:	let-381 / 172331	WormBaseID:	WBGene00002601	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	318	Identity:	84/318 - (26%)
Similarity:	129/318 - (40%)	Gaps:	64/318 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 IYS------PLKI--SIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNNYGNNNTQD 438
            |||      |||:  :.|....:        ||.|.|         :......:||...:.:::|
Worm     7 IYSLANALGPLKLDSTAPNNSHR--------TIKAEN---------YFNEDEEDYNENSHEDSED 54

  Fly   439 LFQT---PSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQN 500
            ..:.   ....|....||||:||..||..|||..|||:.||:.|||::.:::.::|.| ..||:|
Worm    55 SKEDSDGQGCRSRKRKEKPPFSYIALIAMAISKRPDKKATLAEIYSYLQENFEFFRGE-YAGWRN 118

  Fly   501 SIRHNLSLNRYFIKVARSQDEP---GKGSFWRID-------PDSGAKLIDHSYKKRRQRSSQGFR 555
            |||||||||..|:|:.:...|.   .||..|.|.       .::|.:.....||.|::....|..
Worm   119 SIRHNLSLNECFVKLPKDTGESYRGRKGHKWTISDSCEFMLEENGFRRRPRGYKARKRTHFPGVT 183

  Fly   556 PPY-----GMPRSAPVSPSHMDNSRESS---PLQDIVLQSAPG-SPGMSLEQRAADPEIIYNSQN 611
            ...     |.....|.|.:.:.:|..||   .:::|:|..... .|.:|.:..::....:..|.|
Worm   184 ASNEMGIGGATFDYPSSTTELTDSGTSSLNTDVKNILLNGGEDFGPSISDQLVSSTTSAVLPSLN 248

  Fly   612 AHQQQQQQQQQQQQQTLSNNSNQYSSGS---PYYVTN------------QSSGVATPQ 654
            ...|...........| :....|::|.:   |||.|.            ..|...|||
Worm   249 GPDQSPIYPNYFGYGT-AEFPMQWASPTYDWPYYATPHIGLCSSDFPGISPSPTVTPQ 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	40/96 (42%)
let-381	NP_491826.1	Forkhead	71..160	CDD:365978	40/89 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820