DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and Foxd4

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_032048.1	Gene:	Foxd4 / 14237	MGIID:	1347467	Length:	444	Species:	Mus musculus

Alignment Length:	356	Identity:	103/356 - (28%)
Similarity:	157/356 - (44%)	Gaps:	68/356 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 QTPSTASYNHNE--KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIR 503
            :||:|.:.:..:  ||||||..||..||..:|.|:||||||.:||...:||||::. ..||||||
Mouse    89 RTPATTTADGPQPAKPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKF-PAWQNSIR 152

  Fly   504 HNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYG----MPRSA 564
            ||||||..|:|:.|....||||::|.:||.|.....:.|:.:||:|..: ..||.|    .|...
Mouse   153 HNLSLNDCFVKIPREPGHPGKGNYWSLDPASQDMFDNGSFLRRRKRFKR-HHPPSGGHPHCPFPP 216

  Fly   565 PVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAADP-------------EIIYNSQNAHQQQ 616
            |..|:.:..|:.|..|:    .|||..|.::... ||.|             ..:..:..|:...
Mouse   217 PAVPATLHVSQPSLLLR----YSAPPQPNLAAHP-AAPPRSHPCAPLHPHPMRYLLLAAPAYGDN 276

  Fly   617 QQQQQQQQQQT-LSNNSNQYSSGSPYYVTNQSSGVA--------TPQTHVEGSAASGGGGGGGVG 672
            .::.:.....| |:..:.|...||..:..:||||..        |.::.::|  .:|||.|....
Mouse   277 PRKAEGADPATPLAIPALQPVLGSQPWERDQSSGTRSGRGCASFTIESIMQG--VTGGGTGSAQS 339

  Fly   673 ALLA-LKRNHVMGGGASQH---TLHQQQA------------VAQQQHSEIIYEELPTDYSGHIEA 721
            ...| ....|::     ||   .||.|.|            :..||..    ..||      ::.
Mouse   340 PSFAPWSYCHLL-----QHPPCLLHPQAASPLFHMSAGSRTILPQQPQ----PPLP------LQQ 389

  Fly   722 SEEECVTTATDATVAKRPKYVSEVLXCVRIQ 752
            .:..|..:.......:..:::|.|. .:|.|
Mouse   390 EQHHCAISCAPGKGVRLGQHLSAVAALLRQQ 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	47/86 (55%)
Foxd4	NP_032048.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		Forkhead	103..189	CDD:278670	47/86 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..256		7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820