DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and Foxh1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_032015.1	Gene:	Foxh1 / 14106	MGIID:	1347465	Length:	401	Species:	Mus musculus

Alignment Length:	331	Identity:	84/331 - (25%)
Similarity:	135/331 - (40%)	Gaps:	68/331 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 SPRQGFIQNQ-PNNYNNYGNNNTQDLFQTPSTAS--YNHNEKPPYSYAQLIVQAISAAPDKQLTL 476
            :|.||::... |.:.:.......:.|.:||....  |..::||||:|..:|...|.|||.::|.|
Mouse    23 APAQGYLPCMGPRDNSQLRPPEAESLSKTPKRRKKRYLRHDKPPYTYLAMIALVIQAAPFRRLKL 87

  Fly   477 SGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEP-GKGSFWRID----PDSGA 536
            :.|...:...:|::| :..:||::|||||||.||.|.||.:...:| .||:||.:|    |....
Mouse    88 AQIIRQVQAVFPFFR-DDYEGWKDSIRHNLSSNRCFHKVPKDPAKPQAKGNFWAVDVSLIPAEAL 151

  Fly   537 KLIDHSYKKRRQR--SSQGFR---PPY---GMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPG 593
            :|.:.:..:|.|.  :.:.|.   .||   |.|...|..|        ..|.:...::|..|.||
Mouse   152 RLQNTALCRRWQNRGTHRAFAKDLSPYVLHGQPYQPPSPP--------PPPREGFSIKSLLGDPG 208

  Fly   594 MSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATP----- 653
                :.:..|:        |.....|....|..|||.......:|       .||...||
Mouse   209 ----KESTWPQ--------HPGLPGQSTAAQAGTLSKGEEGMGTG-------PSSSSETPLWPLC 254

  Fly   654 ----QTHVEGSAASGGGGGGGVGALLALKRNHVM--GGGASQHTLH---QQQAVAQQQHSEIIYE 709
                .|.:||.::.|.          .::.:.|.  .|....|.|.   ..:.|.::.....::.
Mouse   255 SLPGPTIIEGESSQGE----------VIRPSPVTPDQGSWPLHLLEDSADSRGVPRRGSRASLWG 309

  Fly   710 ELPTDY 715
            :|||.|
Mouse   310 QLPTSY 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	37/91 (41%)
Foxh1	NP_032015.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57		4/24 (17%)
		FH	64..142	CDD:238016	34/78 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..251		21/98 (21%)
		SMAD-interaction domain (SID)	307..390		4/9 (44%)
		Fast/FoxH1 motif 1 (FM1)	311..315		3/3 (100%)
		Fast/FoxH1 motif 2 (FM2)	321..327
		SMAD interaction motif (SIM)	363..384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820