DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxl1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_012817795.1	Gene:	foxl1 / 100038263	XenbaseID:	XB-GENE-5880620	Length:	406	Species:	Xenopus tropicalis

Alignment Length:	333	Identity:	90/333 - (27%)
Similarity:	140/333 - (42%)	Gaps:	78/333 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 EKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVA 516
            :||||||..||..||..:||.::||:|||.||:..:|:|. :..:|||||||||||||..||||.
Frog    50 QKPPYSYIALIAMAIKDSPDHRVTLNGIYQFIMDRFPFYH-DNKQGWQNSIRHNLSLNDCFIKVP 113

  Fly   517 RSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR-----SSQGFR-----PPYGMPRSA------- 564
            |.:..|||||:|.:||.......:.::::|:::     ..:|.|     ..|.:..:|
Frog   114 REKGRPGKGSYWTLDPKCLDMFENGNFRRRKRKPKPILCQEGKRHKAEAAEYRLADAACKGTTCK 178

  Fly   565 ------------------PVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAADPEIIYNSQN 611
                              |.|....|::.|.|..:|      .|..|..::...| ||
Frog   179 VAGNTGQNGSQDAPLGRKPTSACEKDSAGEMSSSED------EGGSGDYIKTSPA-PE------- 229

  Fly   612 AHQQQQQQQQQQQQQTLSNNSNQYSSGSP-YYVT--------NQSSGVATPQTHVEGSAASGGGG 667
            .|.|::            .:...::|..| :||:        ..||.....|.|.:|:.....|.
Frog   230 CHNQER------------TSGTYWNSLHPSFYVSVPLLSDQVTLSSKREGSQAHEQGNRLLACGA 282

  Fly   668 GGGVGALLALKRNHVMGGGASQHTLHQQQAVAQQQHSEIIYEELPTDYSGHIEASEEECVTTATD 732
            .|.:||......|.  ..||:.....:.:.::|:.......:.:    ....:.|..||...|..
Frog   283 QGHLGAPSPGSNNE--KAGATDANCKEAEQLSQKSARSFSIDSI----LSRSDQSAPECGAPAPP 341

  Fly   733 ATVAKRPK 740
            | |:|.|:
Frog   342 A-VSKVPE 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	47/86 (55%)
foxl1	XP_012817795.1	Forkhead	50..136	CDD:365978	47/86 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950