DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7638 and tmem161a

DIOPT Version :9

Sequence 1:	NP_648439.1	Gene:	CG7638 / 39250	FlyBaseID:	FBgn0036133	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001037782.1	Gene:	tmem161a / 492692	ZFINID:	ZDB-GENE-041111-267	Length:	495	Species:	Danio rerio

Alignment Length:	509	Identity:	179/509 - (35%)
Similarity:	291/509 - (57%)	Gaps:	35/509 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVLGAQLVITLVMVSVIQKLSPHYSFAKWILCRTGLYRYLHPTDDELRSRGGVPKEKPPKGGRN 65
            ||::|.|||::|:.||::|:::||.|||:|:||...|.::.||::.||.:..|  |:.|....|:
Zfish     1 MALMGVQLVVSLLAVSIMQRMAPHLSFARWLLCNGSLLKFRHPSEGELCALAG--KQIPKTSRRD 63

  Fly    66 KQANGSGGAAGAQFHIPRSIEVELLTSPVLERDVVHLRYFTEYQWLLDFSVYTGIVYVVSELFHF 130
            ::.||.|  ......:|:.|::.|.::||...|.:.||:|.|||||:||:||...:|:.:|.::.
Zfish    64 RRQNGHG--ESKPLTVPKDIDLHLESTPVNVMDALVLRFFVEYQWLIDFAVYATGIYLFTEGYYS 126

  Fly   131 YYPLRHEVNLSMVWCLLVIFFALKLLSSLTVLYFQSEESIGERSMVIVACLVYLLVAMVVLIVDE 195
            ......|||::.:||:|.:.|.|:.|..|...||.|||. ||||:.:....:.||:||:||:|.|
Zfish   127 VVDASKEVNIASIWCVLTVLFCLRTLYLLMSHYFLSEEG-GERSVCLAFGFLSLLIAMLVLVVRE 190

  Fly   196 RILETGLEDAYASFNASASKFLTEQGLPSSGPASKIVVKFFLAMGCGLLGSLFTFPGLRMAKMHW 260
            ..||.|||..:.|...:...|..:||...|.|.:|:.||..||:.|..:|:|..|||||:|:.|.
Zfish   191 DYLEFGLEPGFTSLFDNFEVFARKQGYEWSVPFTKLSVKLGLAVICAFIGALLAFPGLRLAQTHL 255

  Fly   261 DSLKYCRGNRLLQVLLNLSFVLPFILVILWIRPISRDYLTVRVFQGMQQPLLKPHVFETLRLLLV 325
            |:::......::|:||::||:.|.:::::||:||:||:|...........||....|.::||..:
Zfish   256 DAVQMNADRPMIQILLHMSFLSPLVIIVMWIKPIARDFLGNAPMGKTSVTLLSSSAFSSVRLWTI 320

  Fly   326 IFVVVVRFALMPIYLQSYLNLAHDKIMDLRKEAGRITNVEFKQKISSIFYYLCVVTLQFAAPLIL 390
            :.:..:|..|...:||:|||||...:..::||||||..::.::|::.||.||.|||||:..|::|
Zfish   321 VVLCFLRLLLTRYHLQAYLNLAQKWVEQMKKEAGRIAAIDIQRKVTRIFCYLTVVTLQYLIPILL 385

  Fly   391 CLYLTLMYKSLGGFSWSGIFRESVVLQHECAASETEGAGVA----------VSQGDGDFNIIESA 445
            .|:.||..||||.|||.             ..:||.|...|          |...:.|.::.:..
Zfish   386 VLFSTLALKSLGDFSWG-------------LGAETPGVSPAPIIPSSTPPPVPGPEDDEDMEDME 437

  Fly   446 QSLQAS-------FSSLKNVFSTEVYKGFLGFATWWSYFTLFATSSLGIVYQSY 492
            :.:||:       ||:|:.:.:...::|...|.|||.......:|..||.:..|
Zfish   438 EDIQATVAHLTELFSALRALLTPIFFRGIFAFLTWWVAACQLISSLFGIYFHQY 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7638	NP_648439.1	Tmemb_161AB	2..493	CDD:287270	178/508 (35%)
tmem161a	NP_001037782.1	Tmemb_161AB	2..492	CDD:287270	178/508 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583619
Domainoid	1	1.000	396	1.000	Domainoid score	I727
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1898
OMA	1	1.010	-	-		QHG59375
OrthoDB	1	1.010	-	-		D385367at33208
OrthoFinder	1	1.000	-	-		FOG0002601
OrthoInspector	1	1.000	-	-		otm24547
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13624
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4356
SonicParanoid	1	1.000	-	-		X1956
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.040