DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7638 and Tmem161a

DIOPT Version :9

Sequence 1:	NP_648439.1	Gene:	CG7638 / 39250	FlyBaseID:	FBgn0036133	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001102344.1	Gene:	Tmem161a / 364535	RGDID:	1307703	Length:	479	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	176/499 - (35%)
Similarity:	281/499 - (56%)	Gaps:	31/499 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVLGAQLVITLVMVSVIQKLSPHYSFAKWILCRTGLYRYLHPTDDELRSRGGVPKEKPPKGGRN 65
            |||||.|||:||...:::.:|:||.|||:|:||...|:||:||:::|||:..|.|:   |:|.:.
  Rat     1 MAVLGVQLVVTLFTATLMHRLAPHCSFARWLLCNGSLFRYIHPSEEELRALAGKPR---PRGRKE 62

  Fly    66 KQANGSGGAAGAQFH------IPRSIEVELLTSPVLERDVVHLRYFTEYQWLLDFSVYTGIVYVV 124
            :.||        ..|      :||....:|.|.|:...|.:.||:|.||||.:||:||:..||:.
  Rat    63 RWAN--------SLHDEKPLSVPRDAHFQLETCPLTAVDALVLRFFLEYQWFVDFAVYSVGVYLF 119

  Fly   125 SELFHFYYPLRHEVNLSMVWCLLVIFFALKLLSSLTVLYFQSEESIGERSMVIVACLVYLLVAMV 189
            :|.::|......|.|:::.||||.:.|:||:...:|.|||.|:|. ||||:.:....::||:||:
  Rat   120 TEAYYFVLGPVQETNIAVFWCLLTLAFSLKVFLMVTRLYFSSKEG-GERSVCLSFAFLFLLLAML 183

  Fly   190 VLIVDERILETGLEDAYASFNASASKFLTEQGLPSSGPASKIVVKFFLAMGCGLLGSLFTFPGLR 254
            |.:|.|..||.|||...||........|.:|....:.|..|:.::..||:...|||:...|||||
  Rat   184 VQVVREETLELGLEPGLASMTQHLEPVLKKQDWDWTLPVIKLSIRLGLAVLGSLLGAFLIFPGLR 248

  Fly   255 MAKMHWDSLKYCRGNRLLQVLLNLSFVLPFILVILWIRPISRDYLTVRVFQGMQQPLLKPHVFET 319
            :|:.|.|:|.......|||:||:.||:.|...:.||.:|::||:|.....:.|...:....||::
  Rat   249 LAQTHQDALTLSADRPLLQLLLHTSFLSPLCTLWLWTKPVARDFLYQAPMRNMTFSVPSEEVFDS 313

  Fly   320 LRLLLVIFVVVVRFALMPIYLQSYLNLAHDKIMDLRKEAGRITNVEFKQKISSIFYYLCVVTLQF 384
            |||.:::.:.::|..:...:||:||.||..::..||||||||...|.:|::..::.|:.||:||:
  Rat   314 LRLWVLVVLCLLRLVVTRPHLQAYLCLAKARVEQLRKEAGRIEAREVQQRVVRVYCYVTVVSLQY 378

  Fly   385 AAPLILCLYLTLMYKSLGGFSWSGIFRESVVLQHECAASETEGAGVAVSQGDGDFNIIESAQSLQ 449
            ..||||.|:.||:.|:|||:||:     .....|..|.|:.....::|...|       .||...
  Rat   379 LTPLILTLHCTLLLKTLGGYSWA-----LSPTPHPLAPSQPSETLISVDPAD-------EAQQTA 431

  Fly   450 ASFSSLKNVFSTEVY-KGFLGFATWWSYFTLFATSSLGIVYQSY 492
            |..:.:.....|.:: :|.|.:..||:......:|..|:.:..:
  Rat   432 AQVAGILGGLLTPLFLRGVLAYIIWWTAACQLLSSLFGLYFHQH 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7638	NP_648439.1	Tmemb_161AB	2..493	CDD:287270	175/498 (35%)
Tmem161a	NP_001102344.1	Tmemb_161AB	2..476	CDD:287270	175/498 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343363
Domainoid	1	1.000	357	1.000	Domainoid score	I945
eggNOG	1	0.900	-	-		E1_KOG3978
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2142
OMA	1	1.010	-	-		QHG59375
OrthoDB	1	1.010	-	-		D385367at33208
OrthoFinder	1	1.000	-	-		FOG0002601
OrthoInspector	1	1.000	-	-		otm44653
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13624
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1956
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870