Protein Alignment APP-BP1 and AOS1

DIOPT Version :9

• Sequence 1: NP_001261699.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_015506.1
• Gene: AOS1 / 856310
• SGDID: S000006384
• Length: 347
• Species: Saccharomyces cerevisiae
• Alignment Length: 516
• Identity: 119/516 - (23%)
• Similarity: 190/516 - (36%)
• Gaps: 182/516 - (35%)

  Fly     7 KSPELS-DKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTV 70
            |..:|| |:...|||||||||...|..:.:|.|.|:|:.|:|.|..|.:||.|||..|:.||..|
Yeast     4 KVEKLSEDEIALYDRQIRLWGMTAQANMRSAKVLLINLGAIGSEITKSIVLSGIGHLTILDGHMV 68

  Fly    71 KEEDLGNNFFLDSSYLGKSKALACMQLLQELNP--DVNGDYVDESADFLLANRPNFFDSFDLVIA 133
            .|||||:.||:.|..:|:.|..|..:.:|:|||  ::|.|..|     |......||..||||:|
Yeast    69 TEEDLGSQFFIGSEDVGQWKIDATKERIQDLNPRIELNFDKQD-----LQEKDEEFFQQFDLVVA 128

  Fly   134 SNLNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALR 198
            :.:.....:.:.....:||:||....|.|:...:.:.:.|                    |.:..
Yeast   129 TEMQIDEAIKINTLTRKLNIPLYVAGSNGLFAYVFIDLIE--------------------FISED 173

  Fly   199 EHLDGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIK 263
            |.|.....|:..|                        ....::.::.|.|::.:.:::.||. ||
Yeast   174 EKLQSVRPTTVGP------------------------ISSNRSIIEVTTRKDEEDEKKTYER-IK 213

  Fly   264 AVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPDMTAN 328
            ..|                    |                           :.||..||...|
Yeast   214 TKN--------------------C---------------------------YRPLNEVLSTAT-- 229

  Fly   329 TDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIAE 393
                                         ||      :.:.:|.::.:
Yeast   230 -----------------------------LK------EKMTQRQLKRV----------------- 242

  Fly   394 EYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDL 458
                 :.:|||        .|:...:.|           |..|:.|   ...::|..||....:|
Yeast   243 -----TSILPL--------TLSLLQYGL-----------NQKGKAI---SFEQMKRDAAVWCENL 280

  Fly   459 GMHAT-ISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIYNAITTE 518
            |:.|| :.||.:.:..:..|.|...|:|.|||..||:||.|:.|:..|::|..:::.||.:
Yeast   281 GVPATVVKDDYIQQFIKQKGIEFAPVAAIIGGAVAQDVINILGKRLSPLNNFIVFDGITLD 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	115/506 (23%)
		ThiF	17..>171	CDD:223552	59/155 (38%)
AOS1	NP_015506.1	Aos1_SUMO	13..345	CDD:238769	115/507 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I951
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I1081
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1600
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.890