DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP-BP1 and UBA1

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_012712.1	Gene:	UBA1 / 853670	SGDID:	S000001693	Length:	1024	Species:	Saccharomyces cerevisiae

Alignment Length:	577	Identity:	117/577 - (20%)
Similarity:	207/577 - (35%)	Gaps:	132/577 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSPAPKSPELSDK-----SKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGG 61
            |.|.||:...::|     :.:||.||.::|...|..:..:.|.||...|:|||..|...|.|:|.
Yeast   396 SLPDPKNFPRNEKTTQPVNSRYDNQIAVFGLDFQKKIANSKVFLVGSGAIGCEMLKNWALLGLGS 460

  Fly    62 -----FTVADGSTVKEEDLGNNFFLDSSYLGKSKALACMQLLQELNPDVNG------DYVDESAD 115
                 ..|.|..::::.:|...|......:||:|:....:.:..:|||:.|      |.|....:
Yeast   461 GSDGYIVVTDNDSIEKSNLNRQFLFRPKDVGKNKSEVAAEAVCAMNPDLKGKINAKIDKVGPETE 525

  Fly   116 FLLANRPNFFDSFDLVIASNLNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAH 180
            .:.  ..:|::|.|.|..:..|......:..|......||:...:||..|..::.|..  :.|::
Yeast   526 EIF--NDSFWESLDFVTNALDNVDARTYVDRRCVFYRKPLLESGTLGTKGNTQVIIPR--LTESY 586

  Fly   181 PDN-------------RQFDLRLEHPFDALREHLDG--TEVTSKVPWLLVLHKYLNVWQKQQADG 230
            ..:             |.|..:::|.....:....|  |:....|...|....::....||..|
Yeast   587 SSSRDPPEKSIPLCTLRSFPNKIDHTIAWAKSLFQGYFTDSAENVNMYLTQPNFVEQTLKQSGD- 650

  Fly   231 TQTPRNYKEKNQLKETIREEMKADEENYEEAIKAVNTAFGA--GQVPKSLKAIFEDDACEQLNKK 293
                    .|..| |:|.:.:.:...|:|:.||.....|..  ....|.|...|..||     |.
Yeast   651 --------VKGVL-ESISDSLSSKPHNFEDCIKWARLEFEKKFNHDIKQLLFNFPKDA-----KT 701

  Fly   294 SN--VFWIMAKALK---HFVIHENEG-HLPLPGVL------------PDMTANTDSY-IALQHIY 339
            ||  .||..||...   .|.|:.|:. |..:.|..            .:...|.|.| ..:.|:.
Yeast   702 SNGEPFWSGAKRAPTPLEFDIYNNDHFHFVVAGASLRAYNYGIKSDDSNSKPNVDEYKSVIDHMI 766

  Fly   340 RQQALQDAD---QVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIAE-EYEKSSR 400
            ..:...:|:   ||.....:.....|..:|.||:     :.......:.:.|.::.. ::||
Yeast   767 IPEFTPNANLKIQVNDDDPDPNANAANGSDEIDQ-----LVSSLPDPSTLAGFKLEPVDFEK--- 823

  Fly   401 LLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGE--CIVEQDIGRLKSIAAKMLSDLGMHAT 463
                  |::...::           .|::.|.|...:  .|...|..:.|.||.:::..:.
Yeast   824 ------DDDTNHHI-----------EFITACSNCRAQNYFIETADRQKTKFIAGRIIPAIA---- 867

  Fly   464 ISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKII-----TKQYKPIDNTFIYNAI 515
                              ..::.:.|....|:.|:|     .:|||   |.|:..|:
Yeast   868 ------------------TTTSLVTGLVNLELYKLIDNKTDIEQYK---NGFVNLAL 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	112/558 (20%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	41/164 (25%)
UBA1	NP_012712.1	Ube1	13..1023	CDD:273603	117/577 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810