Protein Alignment APP-BP1 and Nae1

DIOPT Version :10

• Sequence 1: NP_648435.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_114461.3
• Gene: Nae1 / 84019
• RGDID: 619945
• Length: 534
• Species: Rattus norvegicus
• Alignment Length: 533
• Identity: 240/533 - (45%)
• Similarity: 341/533 - (63%)
• Gaps: 29/533 - (5%)

  Fly    14 KSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNN 78
            |.:|||||:||||:|||..||:|.|||:|.||.|.|..|.|||||||.||:.||:.|..||:|||
  Rat     9 KEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDVGNN 73

  Fly    79 FFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTLLL 143
            |||....:||::|.|.|:.|||||.||:|.:|:||.:.||.|.|:||..|.:|:|:.|.|.|||.
  Rat    74 FFLQKCSIGKNRAQAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTIVVATQLLESTLLR 138

  Fly   144 LAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVT- 207
            ||:.||...:||:.||:.|::|.:|:.|:||.::|:||||...||||:.||..||||....::.
  Rat   139 LADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDH 203

  Fly   208 ------SKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEM-------KADEENYE 259
                  |..||::::.|||..|. .:.:| :.|::||||...:|.||:.:       ..||||:|
  Rat   204 MEKKDHSHTPWIVIIAKYLAQWY-SETNG-RIPKSYKEKEDFRELIRQGILKNENGAPEDEENFE 266

  Fly   260 EAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPD 324
            ||||.||||....|:|.|::.||.||.|..:.|::..|||:|:|||.||..|.:|:||:.|.:||
  Rat   267 EAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPD 331

  Fly   325 MTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGT 389
            |.|::..||.||::||::|.:||..|.:...:.|:.:....:||.|:.::|:|..:|.|.|:|..
  Rat   332 MIADSSKYIKLQNVYREKAKKDAAAVGNHVAKLLQSVGQAPESISEKELKLLCSNSAFLRVVRCR 396

  Fly   390 RIAEEY----EKSSRLLPLVE--DNELQGNLTAYNFALRAYERFLSECGNIPG--ECIVEQDIGR 446
            .:||||    .....::..::  |||:     .....|||.:||..:.|..||  ...||:|||:
  Rat   397 SLAEEYGLHTVNKDEIISSMDNPDNEI-----VLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIGK 456

  Fly   447 LKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFI 511
            |||.....|.:.|:...:.||.:||.||||.||.|.|:||:||.||||||||||||:...:||:|
  Rat   457 LKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTVAAFLGGAAAQEVIKIITKQFVIFNNTYI 521

  Fly   512 YNAITTESVTLKL 524
            |:.::..|.|.:|
  Rat   522 YSGMSQTSATFQL 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_648435.1	APPBP1_RUB	16..522	CDD:238770	237/527 (45%)
Nae1	NP_114461.3	APPBP1_RUB	11..532	CDD:238770	237/527 (45%)
		Interaction with UBA3. /evidence=ECO:0000250	331..344		6/12 (50%)