DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP-BP1 and Nae1

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_114461.3	Gene:	Nae1 / 84019	RGDID:	619945	Length:	534	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	240/533 - (45%)
Similarity:	341/533 - (63%)	Gaps:	29/533 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNN 78
            |.:|||||:||||:|||..||:|.|||:|.||.|.|..|.|||||||.||:.||:.|..||:|||
  Rat     9 KEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDVGNN 73

  Fly    79 FFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTLLL 143
            |||....:||::|.|.|:.|||||.||:|.:|:||.:.||.|.|:||..|.:|:|:.|.|.|||.
  Rat    74 FFLQKCSIGKNRAQAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTIVVATQLLESTLLR 138

  Fly   144 LAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVT- 207
            ||:.||...:||:.||:.|::|.:|:.|:||.::|:||||...||||:.||..||||....::.
  Rat   139 LADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDH 203

  Fly   208 ------SKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEM-------KADEENYE 259
                  |..||::::.|||..|. .:.:| :.|::||||...:|.||:.:       ..||||:|
  Rat   204 MEKKDHSHTPWIVIIAKYLAQWY-SETNG-RIPKSYKEKEDFRELIRQGILKNENGAPEDEENFE 266

  Fly   260 EAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPD 324
            ||||.||||....|:|.|::.||.||.|..:.|::..|||:|:|||.||..|.:|:||:.|.:||
  Rat   267 EAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPD 331

  Fly   325 MTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGT 389
            |.|::..||.||::||::|.:||..|.:...:.|:.:....:||.|:.::|:|..:|.|.|:|..
  Rat   332 MIADSSKYIKLQNVYREKAKKDAAAVGNHVAKLLQSVGQAPESISEKELKLLCSNSAFLRVVRCR 396

  Fly   390 RIAEEY----EKSSRLLPLVE--DNELQGNLTAYNFALRAYERFLSECGNIPG--ECIVEQDIGR 446
            .:||||    .....::..::  |||:     .....|||.:||..:.|..||  ...||:|||:
  Rat   397 SLAEEYGLHTVNKDEIISSMDNPDNEI-----VLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIGK 456

  Fly   447 LKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFI 511
            |||.....|.:.|:...:.||.:||.||||.||.|.|:||:||.||||||||||||:...:||:|
  Rat   457 LKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTVAAFLGGAAAQEVIKIITKQFVIFNNTYI 521

  Fly   512 YNAITTESVTLKL 524
            |:.::..|.|.:|
  Rat   522 YSGMSQTSATFQL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	237/527 (45%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	85/153 (56%)
Nae1	NP_114461.3	ThiF	9..>193	CDD:223552	100/183 (55%)
		APPBP1_RUB	11..532	CDD:238770	237/527 (45%)
		Interaction with UBA3. /evidence=ECO:0000250	331..344		6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335398
Domainoid	1	1.000	442	1.000	Domainoid score	I519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68370
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1508
OMA	1	1.010	-	-		QHG54417
OrthoDB	1	1.010	-	-		D393419at33208
OrthoFinder	1	1.000	-	-		FOG0003676
OrthoInspector	1	1.000	-	-		oto96876
orthoMCL	1	0.900	-	-		OOG6_101722
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3040
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910