DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP-BP1 and AXR1

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_172010.1	Gene:	AXR1 / 839286	AraportID:	AT1G05180	Length:	540	Species:	Arabidopsis thaliana

Alignment Length:	532	Identity:	197/532 - (37%)
Similarity:	315/532 - (59%)	Gaps:	18/532 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KSPELSDKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVK 71
            :.|.:.:...|||||:|:|||.||..||.|::||:|....|.|..|.|||.|:|..||.|||.|:
plant    13 EEPTMVEPKTKYDRQLRIWGEVGQAALEEASICLLNCGPTGSEALKNLVLGGVGSITVVDGSKVQ 77

  Fly    72 EEDLGNNFFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASNL 136
            ..||||||.:|:..:|:|||.:....|||||..||..:::|:.|.|:...|:||..|.||||:.|
plant    78 FGDLGNNFMVDAKSVGQSKAKSVCAFLQELNDSVNAKFIEENPDTLITTNPSFFSQFTLVIATQL 142

  Fly   137 NEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHL 201
            .|.::|.|.....:.||.|:..||.|:.|.:|:.::||.|:::.||:...||||.:|:..|:..:
plant   143 VEDSMLKLDRICRDANVKLVLVRSYGLAGFVRISVKEHPIIDSKPDHFLDDLRLNNPWPELKSFV 207

  Fly   202 DGTEVT--------SKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEM-KADEEN 257
            :..::.        ..:|::::|.|....|  .|:.....|...:||.:.|:.::.:| ..||:|
plant   208 ETIDLNVSEPAAAHKHIPYVVILVKMAEEW--AQSHSGNLPSTREEKKEFKDLVKSKMVSTDEDN 270

  Fly   258 YEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVL 322
            |:|||:|....|....:...::.:. :|:|.::|..|:.||:|..|||.||::|..|..||.|.:
plant   271 YKEAIEAAFKVFAPRGISSEVQKLI-NDSCAEVNSNSSAFWVMVAALKEFVLNEGGGEAPLEGSI 334

  Fly   323 PDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIR 387
            ||||::|:.||.||.||..:|..|...:..:.:..||::.....||.:.:::..||.|..|.:.|
plant   335 PDMTSSTEHYINLQKIYLAKAEADFLVIEERVKNILKKIGRDPSSIPKPTIKSFCKNARKLKLCR 399

  Fly   388 GTRIAEEYEKSS--RLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECI--VEQDIGRLK 448
            ...:.:|:...|  .:...:.|.:..|.:..| ..|||.:||.:.....||:..  :::||.|||
plant   400 YRMVEDEFRNPSVTEIQKYLADEDYSGAMGFY-ILLRAADRFAANYNKFPGQFDGGMDEDISRLK 463

  Fly   449 SIAAKMLSDLGMHATI-SDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIY 512
            :.|..:|:|||.:.:: .||::||:||:|.:|:|.||||:||.|:|||||::|||:.|:..|:|:
plant   464 TTALSLLTDLGCNGSVLPDDLIHEMCRFGASEIHVVSAFVGGIASQEVIKLVTKQFVPMLGTYIF 528

  Fly   513 NAITTESVTLKL 524
            |.|..:|..|||
plant   529 NGIDHKSQLLKL 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	193/519 (37%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	72/153 (47%)
AXR1	NP_172010.1	APPBP1_RUB	22..538	CDD:238770	193/519 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	348	1.000	Domainoid score	I228
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68370
Inparanoid	1	1.050	369	1.000	Inparanoid score	I570
OMA	1	1.010	-	-		QHG54417
OrthoDB	1	1.010	-	-		D454386at2759
OrthoFinder	1	1.000	-	-		FOG0003676
OrthoInspector	1	1.000	-	-		otm3129
orthoMCL	1	0.900	-	-		OOG6_101722
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840