DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment APP-BP1 and Uba7

DIOPT Version :9

Sequence 1:NP_001261699.1 Gene:APP-BP1 / 39244 FlyBaseID:FBgn0261112 Length:524 Species:Drosophila melanogaster
Sequence 2:NP_076227.1 Gene:Uba7 / 74153 MGIID:1349462 Length:977 Species:Mus musculus


Alignment Length:514 Identity:107/514 - (20%)
Similarity:178/514 - (34%) Gaps:156/514 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 YDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLD 82
            |.||:.:.|......::.|.|.|..:..:|.|.||.|||.|:|..|:.|.......||....||.
Mouse     6 YSRQLYVLGLPAMQRIQEAKVLLCGLQGLGAEVAKNLVLTGVGSLTLHDPHPTCWADLAAQCFLS 70

  Fly    83 SSYLGKSKALACMQLLQELNPDV-----NGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTLL 142
            ...||:::|.|....|.:||..|     :||..::           ....|.:|:.::...:..|
Mouse    71 EESLGRNRAEASQAQLAQLNEAVQISVHSGDITED-----------LLQGFQVVVLTDSKLEDQL 124

  Fly   143 LLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVT 207
            .:.....:..|..:...:.|::|.:.....|...|                       ||.|||.
Mouse   125 KVGPLCHKHGVRFLMAETRGLVGRLFCDFGEDFTV-----------------------LDPTEVE 166

  Fly   208 SKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKE---TIREEMKADEENYEEAIKAVNTAF 269
               |....:...     .|...|..|.|...:::...:   .|..::        |.:..:|:. 
Mouse   167 ---PMTAAIQDI-----SQGFPGIVTLRGDTKRHSFHDGDLVIFSDI--------EGMVELNSC- 214

  Fly   270 GAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHE-----NEGHLPLPGVL--PDMTA 327
                .|:|::.  :.|...::...:.    .::.|:..|:.|     ...|.||...|  |.:.|
Mouse   215 ----SPQSVRV--QKDGSLEIGDTTT----FSRYLRGGVVTEVKRPKTVRHKPLDIALLQPHVVA 269

  Fly   328 -NTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRI 391
             ||      |.:.|...|..|..|.||.|:...:|..|.|..|..:|   .:.|..|..::||  
Mouse   270 QNT------QEVQRAHCLHQAFHVLHKFQQLHGRLPKPWDPDDAETV---VELAQDLEPLKGT-- 323

  Fly   392 AEEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLS 456
                          |:..|                                |...|::||   ||
Mouse   324 --------------EEESL--------------------------------DEALLRTIA---LS 339

  Fly   457 DLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIYNAI 515
            ..|                   .|..::|.:||.|||||:|.|::::.|:|....::|:
Mouse   340 SAG-------------------TLSPMAAIMGGVAAQEVLKAISRKFMPLDQWLYFDAL 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APP-BP1NP_001261699.1 APPBP1_RUB 16..522 CDD:238770 107/514 (21%)
ThiF 17..>171 CDD:223552 38/157 (24%)
Uba7NP_076227.1 Ube1 1..961 CDD:273603 107/514 (21%)
Ube1_repeat1 5..386 CDD:238768 107/514 (21%)
E1_4HB 254..317 CDD:292809 22/71 (31%)
E1_enzyme_family 421..932 CDD:304554
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0476
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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