Protein Alignment APP-BP1 and UBA7

DIOPT Version :10

• Sequence 1: NP_648435.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_003326.2
• Gene: UBA7 / 7318
• HGNCID: 12471
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 107/513 - (20%)
• Similarity: 174/513 - (33%)
• Gaps: 150/513 - (29%)

  Fly    18 YDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLD 82
            |.||:.:.|......::.|.|.:..:..:|.|.||.|||.|:|..|:.|.......||...|.|.
Human    15 YSRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAAQFLLS 79

  Fly    83 SSYLGKSKALACMQLLQELNPDV-----NGDYVDESADFLLANRPNFFDSFDLVI--ASNLNEQT 140
            ...|.:|:|.|..:||.:||..|     .||..:   |.||        .|.:|:  |:.|.||
Human    80 EQDLERSRAEASQELLAQLNRAVQVVVHTGDITE---DLLL--------DFQVVVLTAAKLEEQ- 132

  Fly   141 LLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTE 205
             |.:.....:..|..:...:.|::|.:.....|...|:        |.....|..|..:|
Human   133 -LKVGTLCHKHGVCFLAADTRGLVGQLFCDFGEDFTVQ--------DPTEAEPLTAAIQH----- 183

  Fly   206 VTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKAVNTAFG 270
            ::...|.:|.|.|..|....:..|                                  .|..:..
Human   184 ISQGSPGILTLRKGANTHYFRDGD----------------------------------LVTFSGI 214

  Fly   271 AGQV------PKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVL--PDMTA 327
            .|.|      |:|:. :.||.:.|..:..:...::...|:......:...|..|...|  |.:.|
Human   215 EGMVELNDCDPRSIH-VREDGSLEIGDTTTFSRYLRGGAITEVKRPKTVRHKSLDTALLQPHVVA 278

  Fly   328 NTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIA 392
            .:.     |.::....|..|....||.|....:...|.|.:|..:|       .||        |
Human   279 QSS-----QEVHHAHCLHQAFCALHKFQHLHGRPPQPWDPVDAETV-------VGL--------A 323

  Fly   393 EEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSD 457
            .:.|...|    .|:..|:..|                            |...::::|   ||.
Human   324 RDLEPLKR----TEEEPLEEPL----------------------------DEALVRTVA---LSS 353

  Fly   458 LGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIYNAI 515
            .|:                   |..:.|.:|..|||||:|.|::::.|:|....::|:
Human   354 AGV-------------------LSPMVAMLGAVAAQEVLKAISRKFMPLDQWLYFDAL 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_648435.1	APPBP1_RUB	16..522	CDD:238770	107/513 (21%)
UBA7	NP_003326.2	Ube1	10..1010	CDD:273603	107/513 (21%)
		2 approximate repeats	23..575		104/505 (21%)