Protein Alignment APP-BP1 and UBA1

DIOPT Version :10

• Sequence 1: NP_648435.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: XP_016885266.1
• Gene: UBA1 / 7317
• HGNCID: 12469
• Length: 1109
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 101/521 - (19%)
• Similarity: 175/521 - (33%)
• Gaps: 169/521 - (32%)

  Fly    18 YDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLD 82
            |.||:.:.|......|:.::|.:..:..:|.|.||.::|.|:...|:.|..|.:..||.:.|:|.
Human   106 YSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLR 170

  Fly    83 SSYLGKSKALACMQLLQELNPDV-----NGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTLL 142
            ...:||::|......|.|||..|     .|..|::           |...|.:|:.:|...:..|
Human   171 EEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVED-----------FLSGFQVVVLTNTPLEDQL 224

  Fly   143 LLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVT 207
            .:.|......:.|:...:.|:.|.:.....|..|:.        |...|.|..|:     .:.||
Human   225 RVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILT--------DSNGEQPLSAM-----VSMVT 276

  Fly   208 SKVPWLLVL-----H--------KYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYE 259
            ...|.::..     |        .:..|....:.:|.| |...|.......:|     .|..|:.
Human   277 KDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQ-PMEIKVLGPYTFSI-----CDTSNFS 335

  Fly   260 EAIKA--VNTAFGAGQVPK--SLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPG 320
            :.|:.  |:..    :|||  |.|::                 :.:.|...||:
Human   336 DYIRGGIVSQV----KVPKKISFKSL-----------------VASLAEPDFVV----------- 368

  Fly   321 VLPDMTANTDSYIALQHIYRQQALQDADQVYHK-CQEYLKQLALPADSIDERSVRLICKEAAGLA 384
                    ||    .....|...|....|..|: |.::.:.   |....:|.:..|:   |...|
Human   369 --------TD----FAKFSRPAQLHIGFQALHQFCAQHGRP---PRPRNEEDAAELV---ALAQA 415

  Fly   385 VIRGTRIAEEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKS 449
            |            ::|.||.|:.|.|
Human   416 V------------NARALPAVQQNNL--------------------------------------- 429

  Fly   450 IAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIYNA 514
                           .:|::.::......:|..::|||||.|||||:|..:.::.||.....::|
Human   430 ---------------DEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDA 479

  Fly   515 I 515
            :
Human   480 L 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_648435.1	APPBP1_RUB	16..522	CDD:238770	101/521 (19%)
UBA1	XP_016885266.1	Ube1	100..1106	CDD:273603	101/521 (19%)