DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP-BP1 and nae1

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_956793.1	Gene:	nae1 / 573336	ZFINID:	ZDB-GENE-040426-1552	Length:	533	Species:	Danio rerio

Alignment Length:	541	Identity:	232/541 - (42%)
Similarity:	332/541 - (61%)	Gaps:	33/541 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PKSPELSDKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTV 70
            ||    :.|.::||||:||||:|||..||.|.|||:|.||.|.|..|.|||||||.||:.||..|
Zfish     4 PK----TSKEQRYDRQLRLWGDHGQEALENAHVCLINATASGTEILKNLVLPGIGAFTIVDGHKV 64

  Fly    71 KEEDLGNNFFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASN 135
            ..||:||||||.||.:||::|.|..:||||||.||:|::|:||.|.||.|...||..|.||||..
Zfish    65 SGEDVGNNFFLSSSAIGKNRAQAATELLQELNSDVSGNFVEESPDKLLDNDCEFFHRFSLVIAVQ 129

  Fly   136 LNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREH 200
            |.|.|.|.|...|||..||.:.||:.|::|.:||.::||.:||:||||...||||:.||..|:.|
Zfish   130 LPESTCLGLGAVLWEAGVPFLVCRTYGLIGYMRLIVKEHTVVESHPDNALEDLRLDQPFTELKRH 194

  Fly   201 LDGTEVT-------SKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEM------- 251
            ::..::.       |..||::|:.:||..|..:  :.:|.|:|||||...::.:||.:
Zfish   195 VESYDLDNMEKKDHSHTPWIIVVARYLEKWYNE--NNSQLPKNYKEKEAFRQLLREGILKNENGG 257

  Fly   252 KADEENYEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHL 316
            ..||||:|||||.||||....::....:.||..:.||.:..:|:.||:||..::.||.:|..|:|
Zfish   258 LEDEENFEEAIKNVNTALNPTKISSGTQDIFNAEQCENITSQSSSFWVMAHGVRDFVQNEGNGNL 322

  Fly   317 PLPGVLPDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAA 381
            |:.|.:|||.|::|.:|.||::||.:|::||..|....:..|:.:....:||.|:.::|.||.||
Zfish   323 PVRGSIPDMIADSDKFIKLQNVYRDKAMRDAAVVSKHVEMLLQSVGKTPESISEQEIKLFCKNAA 387

  Fly   382 GLAVIRGTRIAEEYE----KSSRLLPLVE--DNELQGNLTAYNFALRAYERFLSECGNIPG--EC 438
            .|.|:|...:|:||.    ....:...::  |:|:     .....||:.:||..:....||  ..
Zfish   388 FLRVVRCRSLADEYSVDTFNKDEITSCMDSPDSEM-----VLYLMLRSVDRFYQQHSRYPGVYNY 447

  Fly   439 IVEQDIGRLKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQY 503
            .||:||.:||.....:|.:..::..:.||.:||.||||.||.|.|:||:||.||||.|||||.|:
Zfish   448 QVEEDINKLKLCVNSLLQEYSLNVNVKDDYIHEFCRYGAAEPHTVAAFLGGSAAQEAIKIITHQF 512

  Fly   504 KPIDNTFIYNAITTESVTLKL 524
            .|.:|||:|||::..|.|.:|
Zfish   513 VPFNNTFLYNAMSQTSATFQL 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	227/527 (43%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	88/153 (58%)
nae1	NP_956793.1	ThiF	6..>164	CDD:223552	88/157 (56%)
		APPBP1_RUB	10..531	CDD:238770	227/527 (43%)
		Interaction with uba3. /evidence=ECO:0000250	330..343		6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574707
Domainoid	1	1.000	431	1.000	Domainoid score	I570
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68370
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1626
OMA	1	1.010	-	-		QHG54417
OrthoDB	1	1.010	-	-		D393419at33208
OrthoFinder	1	1.000	-	-		FOG0003676
OrthoInspector	1	1.000	-	-		oto39262
orthoMCL	1	0.900	-	-		OOG6_101722
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1600
SonicParanoid	1	1.000	-	-		X3040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800