DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment APP-BP1 and uba2

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001017091.1	Gene:	uba2 / 549845	XenbaseID:	XB-GENE-977709	Length:	641	Species:	Xenopus tropicalis

Alignment Length:	438	Identity:	93/438 - (21%)
Similarity:	157/438 - (35%)	Gaps:	102/438 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LLEAAT---VCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALA 93
            |.||.:   :.:|....:|||..|.|||.|.....|.|..|:...:|...|.....::|:|||..
Frog    11 LAEAVSTSRLLVVGAGGIGCELLKNLVLTGFINLDVIDLDTIDVSNLNRQFLFQKKHVGRSKAQV 75

  Fly    94 CMQLLQELNPD----------VNGDYVDESADFLLANRPNFFDSFDLVI------ASNLNEQTLL 142
            ..:.:.:..|:          :|.||..|           ||..|.:|:      |:..:...:.
Frog    76 AKESVLQFCPEANITAYHDSIMNPDYNVE-----------FFKQFTMVMNALDNNAARNHVNRMC 129

  Fly   143 LLAERLWELNVPLIYCRSLGMLG---TIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGT 204
            |.|      .:|||...:.|.||   .::..:.|....:..|..:.|      |...:|
Frog   130 LAA------GIPLIESGTAGYLGQVTVVKKGVTECYECQPKPTQKTF------PGCTIR------ 176

  Fly   205 EVTSKVPWLLVLHKYL--NVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKAVNT 267
            ...|:....:|..|||  .::.::.||....| :..:.....:..:...:|:..|.:..||.|:|
Frog   177 NTPSEPIHCIVWAKYLFNQLFGEEDADQEVAP-DIADPEAAWDPTQAAERANASNVDGDIKRVST 240

  Fly   268 ---AFGAGQVP-KSLKAIFEDDACEQLNKKSNVFWIMAK---ALKHFVIHENEGHLPLPGVLPDM 325
               |...|..| |....:|.||....|.  .:..|...|   .|:...:|..|.
Frog   241 KQWAKSTGYDPIKLFNKLFRDDIKYLLT--MDRLWRKRKPPVPLEWSSLHNKEN----------- 292

  Fly   326 TANTDSYIALQHIYRQQALQ--DADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRG 388
            .:.|.:..:||.:..|:.|.  ...|::.|..|.|:      :.:.|:.              .|
Frog   293 CSETQNESSLQGLKDQKVLDVTSCAQLFSKSVETLR------EQLREKG--------------NG 337

  Fly   389 TRIAEEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERF--LSECGNI 434
            ..:.  ::|...  |.::......||..:.|::....||  .|..|||
Frog   338 AELV--WDKDDP--PAMDFVTAAANLRMHIFSMNMKSRFDVKSMAGNI 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	93/438 (21%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	39/160 (24%)
uba2	NP_001017091.1	Uba2_SUMO	19..442	CDD:238766	90/430 (21%)
		UBA_e1_thiolCys	179..360	CDD:371150	41/218 (19%)
		UAE_UbL	450..536	CDD:373253
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..641
		UBA2_C	549..636	CDD:374424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910