DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment APP-BP1 and Uba2

DIOPT Version :9

Sequence 1:NP_001261699.1 Gene:APP-BP1 / 39244 FlyBaseID:FBgn0261112 Length:524 Species:Drosophila melanogaster
Sequence 2:NP_057891.1 Gene:Uba2 / 50995 MGIID:1858313 Length:638 Species:Mus musculus


Alignment Length:543 Identity:120/543 - (22%)
Similarity:190/543 - (34%) Gaps:151/543 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 LLEAAT---VCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALA 93
            |.||.:   |.:|....:|||..|.|||.|.....:.|..|:...:|...|.....::|:|||..
Mouse    11 LAEAVSGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQV 75

  Fly    94 CMQLLQELNPDVNGDYVDESADFLLANRPN--FFDSFDLVI------ASNLNEQTLLLLAERLWE 150
            ..:.:.:.:|..|   ::...|.::....|  ||..|.||:      |:..:...:.|.|:    
Mouse    76 AKESVLQFHPQAN---IEAHHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAAD---- 133

  Fly   151 LNVPLIYCRSLGMLG---TIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVTSKVPW 212
              ||||...:.|.||   ||:..:.| | .|.||...|      ..|.........:|....:.|
Mouse   134 --VPLIESGTAGYLGQVTTIKKGVTE-C-YECHPKPTQ------RTFPGCTIRNTPSEPIHCIVW 188

  Fly   213 LLVLHKYL--NVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKAVNT---AFGAG 272
            .    |||  .::.::.||...:| :..:.....|....|.:|...|.:..||.::|   |...|
Mouse   189 A----KYLFNQLFGEEDADQEVSP-DRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTG 248

  Fly   273 QVP-KSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLP----GVLPDMTANTDSY 332
            ..| |....:|:||....|.  .:..|...|.             |:|    .|.....||.|. 
Mouse   249 YDPVKLFTKLFKDDIRYLLT--MDKLWRKRKP-------------PVPLDWAEVQSQGEANADQ- 297

  Fly   333 IALQHIYRQQALQDADQVYHKCQEYL---KQLALPADSIDERSVRLICKEAAGLAVIRGTRIAEE 394
                        |:..|:..|.|:.|   ...:|.:.||:...|.| .::..|..:|        
Mouse   298 ------------QNEPQLGLKDQQVLDVKSYASLFSKSIETLRVHL-AEKGDGAELI-------- 341

  Fly   395 YEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLG 459
            ::|...  |.::......||..:.|::....||               ||   ||:|..::..:.
Mouse   342 WDKDDP--PAMDFVTSAANLRMHIFSMNMKSRF---------------DI---KSMAGNIIPAIA 386

  Fly   460 MHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIIT------------KQYKP------- 505
                                  ..:|.|.|....|.:||::            ||..|       
Mouse   387 ----------------------TTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVP 429

  Fly   506 --ID--NTFIYNAITTESVTLKL 524
              :|  ||..|...:...||::|
Mouse   430 CALDPPNTNCYVCASKPEVTVRL 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APP-BP1NP_001261699.1 APPBP1_RUB 16..522 CDD:238770 118/539 (22%)
ThiF 17..>171 CDD:223552 42/152 (28%)
Uba2NP_057891.1 ThiF 9..>175 CDD:279270 49/180 (27%)
Uba2_SUMO 19..442 CDD:238766 114/523 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..233 7/31 (23%)
UAE_UbL 450..536 CDD:291402 1/3 (33%)
UBA2_C 547..633 CDD:292812
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 548..638
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0476
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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