Protein Alignment APP-BP1 and Uba2

DIOPT Version :10

• Sequence 1: NP_648435.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_057891.1
• Gene: Uba2 / 50995
• MGIID: 1858313
• Length: 638
• Species: Mus musculus
• Alignment Length: 543
• Identity: 120/543 - (22%)
• Similarity: 190/543 - (34%)
• Gaps: 151/543 - (27%)

  Fly    32 LLEAAT---VCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALA 93
            |.||.:   |.:|....:|||..|.|||.|.....:.|..|:...:|...|.....::|:|||..
Mouse    11 LAEAVSGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQV 75

  Fly    94 CMQLLQELNPDVNGDYVDESADFLLANRPN--FFDSFDLVI------ASNLNEQTLLLLAERLWE 150
            ..:.:.:.:|..|   ::...|.::....|  ||..|.||:      |:..:...:.|.|:
Mouse    76 AKESVLQFHPQAN---IEAHHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAAD---- 133

  Fly   151 LNVPLIYCRSLGMLG---TIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVTSKVPW 212
              ||||...:.|.||   ||:..:.| | .|.||...|      ..|.........:|....:.|
Mouse   134 --VPLIESGTAGYLGQVTTIKKGVTE-C-YECHPKPTQ------RTFPGCTIRNTPSEPIHCIVW 188

  Fly   213 LLVLHKYL--NVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKAVNT---AFGAG 272
            .    |||  .::.::.||...:| :..:.....|....|.:|...|.:..||.::|   |...|
Mouse   189 A----KYLFNQLFGEEDADQEVSP-DRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTG 248

  Fly   273 QVP-KSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLP----GVLPDMTANTDSY 332
            ..| |....:|:||....|.  .:..|...|.             |:|    .|.....||.|.
Mouse   249 YDPVKLFTKLFKDDIRYLLT--MDKLWRKRKP-------------PVPLDWAEVQSQGEANADQ- 297

  Fly   333 IALQHIYRQQALQDADQVYHKCQEYL---KQLALPADSIDERSVRLICKEAAGLAVIRGTRIAEE 394
                        |:..|:..|.|:.|   ...:|.:.||:...|.| .::..|..:|
Mouse   298 ------------QNEPQLGLKDQQVLDVKSYASLFSKSIETLRVHL-AEKGDGAELI-------- 341

  Fly   395 YEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLG 459
            ::|...  |.::......||..:.|::....||               ||   ||:|..::..:.
Mouse   342 WDKDDP--PAMDFVTSAANLRMHIFSMNMKSRF---------------DI---KSMAGNIIPAIA 386

  Fly   460 MHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIIT------------KQYKP------- 505
                                  ..:|.|.|....|.:||::            ||..|
Mouse   387 ----------------------TTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVP 429

  Fly   506 --ID--NTFIYNAITTESVTLKL 524
              :|  ||..|...:...||::|
Mouse   430 CALDPPNTNCYVCASKPEVTVRL 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_648435.1	APPBP1_RUB	16..522	CDD:238770	118/539 (22%)
Uba2	NP_057891.1	Uba2_SUMO	19..442	CDD:238766	114/523 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..233		7/31 (23%)
		UAE_UbL	450..536	CDD:464286	1/3 (33%)
		UBA2_C	547..633	CDD:465058
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..638