DRSC/TRiP Functional Genomics Resources

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Protein Alignment APP-BP1 and uba3

DIOPT Version :10

Sequence 1:NP_648435.1 Gene:APP-BP1 / 39244 FlyBaseID:FBgn0261112 Length:524 Species:Drosophila melanogaster
Sequence 2:NP_998632.1 Gene:uba3 / 406776 ZFINID:ZDB-GENE-040426-2825 Length:462 Species:Danio rerio


Alignment Length:434 Identity:89/434 - (20%)
Similarity:146/434 - (33%) Gaps:106/434 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 QTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALAC 94
            |.||:...:.::....:|||..|.|.|.|.....|.|..|:...:|...|......:|:.||   
Zfish    63 QFLLDTCKILVIGAGGLGCELLKDLALSGFRHIHVVDMDTIDVSNLNRQFLFRPKDVGRPKA--- 124

  Fly    95 MQLLQELNPDVNGDYVDESADFLLANRP----------------NFFDSF-------DLVIASN- 135
                            :.:|||:....|                .|:..|       |.|||.. 
Zfish   125 ----------------EVAADFVNDRVPGCSVVPHFKKIQDLDETFYRQFHIVVCGLDSVIARRW 173

  Fly   136 LNEQTLLLLAERLWELN----VPLIYCRSLGMLGTIRLQIRE-----HCIVEAHPDNRQFDLRLE 191
            :|...|.||......|:    :|||...:.|..|..|:.:..     .|.:|.:|....|.:...
Zfish   174 MNGMLLSLLIYEDGVLDPSSIIPLIDGGTEGFKGNARVILPGMTACIDCTLELYPPQINFPMCTI 238

  Fly   192 HPFDALREHLDGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEM-KADE 255
            .....|.||.        |.::.:|     :|.|::..|.....:..:...::...::.: :|.|
Zfish   239 ASMPRLPEHC--------VEYVRML-----LWPKEKPFGDGVVLDGDDPKHIQWVYQKSLERAAE 290

  Fly   256 ENYEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPG 320
            .|    |..|......|.|.:.:.|:...:|.......:.||.|...|           ::||..
Zfish   291 FN----ITGVTYRLTQGVVKRIIPAVASTNAVIAAACATEVFKIATSA-----------YVPLNN 340

  Fly   321 VLPDMTANTDS-YIALQHIYRQQALQDADQVYH--------KCQEYLK--------QLALPA--D 366
            .|  :..:.|. |.......|::......||..        |.||.|.        |:..||  .
Zfish   341 YL--VFNDVDGLYTYTFEAERKENCSACSQVPQDMQFTPSAKLQEVLDYLTENASLQMKSPAITT 403

  Fly   367 SIDERSVRLICKEAAGLAVIRGTRIAEEYEKSSRLLPLVEDNEL 410
            ::|.::..|..:..|.:.    .|......|:.:.|.||:..||
Zfish   404 TLDGKNKTLYLQTVASIE----ERTRPNLSKTLKELGLVDGQEL 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APP-BP1NP_648435.1 APPBP1_RUB 16..522 CDD:238770 89/434 (21%)
uba3NP_998632.1 Interaction with ube2m N-terminus. /evidence=ECO:0000250 52..69 3/5 (60%)
Uba3_RUB 70..367 CDD:238765 67/345 (19%)
Interaction with ube2m N-terminus. /evidence=ECO:0000250 156..160 1/3 (33%)
Interaction with ube2m N-terminus. /evidence=ECO:0000250 191..216 6/24 (25%)
Interaction with nedd8. /evidence=ECO:0000250 226..228 0/1 (0%)
Interaction with nae1. /evidence=ECO:0000250 241..247 1/5 (20%)
Interaction with nae1. /evidence=ECO:0000250 291..294 1/6 (17%)
Interaction with ube2m N-terminus. /evidence=ECO:0000250 330..337 2/17 (12%)
Interaction with nedd8. /evidence=ECO:0000250 351..356 1/4 (25%)
Interaction with ube2m core domain. /evidence=ECO:0000250 367..462 19/81 (23%)
E2_bind 377..460 CDD:462611 17/71 (24%)

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