Protein Alignment APP-BP1 and uba2

DIOPT Version :10

• Sequence 1: NP_648435.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: XP_009296132.1
• Gene: uba2 / 406672
• ZFINID: ZDB-GENE-040426-2681
• Length: 641
• Species: Danio rerio
• Alignment Length: 572
• Identity: 114/572 - (19%)
• Similarity: 196/572 - (34%)
• Gaps: 199/572 - (34%)

  Fly    33 LEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALACMQL 97
            |.:..|.:|....:|||..|.|||.|.....|.|..|:...:|...|.....::|||||    |:
Zfish    16 LSSCRVLVVGAGGIGCELLKNLVLTGFKNIEVIDLDTIDVSNLNRQFLFQKKHVGKSKA----QV 76

  Fly    98 LQE------------------LNPDVNGDYVDESADFLLANRPNFFDSFDLVI------ASNLNE 138
            .:|                  :|||.|.:               ||.:|.||:      |:..:.
Zfish    77 AKESVLRFCPSANITAYHDSIMNPDYNVE---------------FFRNFQLVMNALDNRAARNHV 126

  Fly   139 QTLLLLAERLWELNVPLIYCRSLGMLG---------------------------TIRLQIRE--H 174
            ..:.|.|:      :|||...:.|.||                           |||....|  |
Zfish   127 NRMCLAAD------IPLIESGTAGYLGQVTVIKKGQTECYECQPKPTQKTFPGCTIRNTPSEPIH 185

  Fly   175 CIV-----------------EAHPDNRQFDLRLEHPFD----ALREHLDG--TEVTSK------- 209
            |||                 |..||....:... :|.|    |.....||  ..|::|
Zfish   186 CIVWAKYLFNQLFGEEDADQEVSPDTADPEAAW-NPADAAARATASDQDGDIKRVSTKEWARSTG 249

  Fly   210 --------------VPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQL----KETIREEMKADE- 255
                          :.:||.:.|   :|:|::|   ..|..::|.|||    ::.|...:|..:
Zfish   250 YDPIKLFNKLFKDDIMYLLTMDK---LWKKRKA---PLPLEWEEINQLAGSQEQVIGSGLKDQQV 308

  Fly   256 -------ENYEEAIKAVNTAF-----GAGQV-----PKSLKAIFEDDACEQLNKKSNVFWIMAKA 303
                   :.::.:::.:.:..     ||..|     |.::     |......|.:.|||.:..|:
Zfish   309 LGVQGYAQLFQHSVETLRSQLKEKGDGAELVWDKDDPPAM-----DFVTAASNLRMNVFSMNMKS 368

  Fly   304 LKHFVIHENEGHLPLPGVLPDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYL--------KQ 360
              .|.:....|:: :|.:     |.|::.||  .:...:||:..:..:.:|:...        |:
Zfish   369 --RFDVKSMAGNI-IPAI-----ATTNAVIA--GLIVLEALKILNSDFEQCRTIFLNKQPNPRKK 423

  Fly   361 LALPADSIDERSVRLICKEAAGLAV---IRGTRIAEEYEKSSRLLPLVEDNELQGNLTAYNFALR 422
            |.:|.......:...:|.....:.|   :..|.:                ..||..:....|.:.
Zfish   424 LLVPCALDPPNASCYVCASKPEVTVKLNVHKTMV----------------QALQDKILKEKFGMV 472

  Fly   423 AYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLGMH---ATISDDVLHE 471
            |.:..: |.|.  |..::..:.|..::...|.|||.|:.   ...:||.|.:
Zfish   473 APDVQI-EDGK--GTILISSEEGETEANNNKFLSDFGIRNGSRLQADDFLQD 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_648435.1	APPBP1_RUB	16..522	CDD:238770	114/572 (20%)
uba2	XP_009296132.1	Uba2_SUMO	20..440	CDD:238766	94/466 (20%)
		UAE_UbL	448..534	CDD:464286	18/93 (19%)
		UBA2_C	545..628	CDD:465058