DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment APP-BP1 and Atg7

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	334	Identity:	63/334 - (18%)
Similarity:	102/334 - (30%)	Gaps:	145/334 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 EMKADEENYEEAIKAVN-----------------TAFG-AGQVPK----SLKAIFEDDACEQLNK 292
            |:|.|.:...::.:::.                 ||:. ..:.||    ::..|:..:..|:.
  Fly    28 ELKLDHDRLSDSKRSITGHYTNRNASGCLLEVDYTAYNRMAKPPKFSHSAIGTIYNKNTIEEF-- 90

  Fly   293 KSNVFWIMAKALKHFVIHENEGHLPLP-----GVLPDMTANTDSYIALQHIYRQQALQDADQVYH 352
                     |||....:..:||...|.     |.|.|.:..|..::          |..||.
  Fly    91 ---------KALDKLQLLADEGKELLADMCSGGALRDPSLLTRFFV----------LSFADL--- 133

  Fly   353 KCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIAEEYEKSSRLLPLVEDNELQG----- 412
            ||..|....|.|.                                     ||....:|||
  Fly   134 KCHSYYYWFAFPC-------------------------------------PLTPTLKLQGAVQKL 161

  Fly   413 ----NLTAYNFALRAY----ERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLGMHATISDDVL 469
                |.::|..||:|.    :.|.....|      ||::|     ..|:.||.|       ||..
  Fly   162 RDLPNSSSYIMALKALPTESQNFFILYAN------VEKNI-----FEARSLSSL-------DDKN 208

  Fly   470 HEICRYGGAE------------------LHAVSAFIGGCAAQEVIKII---TKQYKPIDNTFIYN 513
            .|.|.:|.|:                  |....:|:|     :.:|.:   ..|...||::.::.
  Fly   209 VEFCYFGFADPSEYEHPAWIMRNYAAFLLQQCPSFVG-----KPLKFLGLRHNQQMNIDDSLVWK 268

  Fly   514 AITTESVTL 522
            .|.||:..|
  Fly   269 VIQTEACDL 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	62/332 (19%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029	63/334 (19%)
		E1_like_apg7	11..682	CDD:273590	63/334 (19%)
		Apg7	341..658	CDD:238763
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446863
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10953
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930