DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment APP-BP1 and Uba1

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	99/545 - (18%)
Similarity:	197/545 - (36%)	Gaps:	140/545 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGI----GGFTVADGSTVKEEDLGN 77
            :||.||.::|:..|..|..:...:|...|:|||..|...:.|:    |...|.|...:::.:|..
  Fly   586 RYDSQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTGNGQIFVTDMDLIEKSNLNR 650

  Fly    78 NFFLDSSYLGKSKALACMQLLQELNPDVNGDYVD--ESADFLLANRPNFFDSFDLVIASNLNEQT 140
            .|......:.|.|::.....::.:||:||....:  ..|:.......:||...| .:|:.|:...
  Fly   651 QFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLD-GVANALDNVD 714

  Fly   141 LLLLAERLWELN-VPLIYCRSLGMLGTIRLQI----REHCIVEAHPDN-------RQFDLRLEHP 193
            ..:..:|....| :||:...:||.||.:::.:    ..:...:..|:.       :.|...:||.
  Fly   715 ARIYMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEHT 779

  Fly   194 FDALREHLDG------------------TEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEK 240
            ....|:..:|                  ||..:|:|.:..|
  Fly   780 LQWARDAFEGVFKQSAENAAQYIADPQFTERIAKLPGIQPL------------------------ 820

  Fly   241 NQLKETIREEMKADE-ENYEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKAL 304
             ::.::|::.:..|: :::...::... .:...|....:|.:..:...:|:......||
  Fly   821 -EILDSIKKALIDDKPKSFAHCVEWAR-LYWEDQYVNQIKQLLFNFPPDQITSSGQPFW------ 877

  Fly   305 KHFVIHENEGHLPLPGVLPD-MTANTDSYIALQHIYRQQALQ----DADQVYHK--CQEYLKQLA 362
                    .|    |...|| :..:.:..:.|..||....|:    ..:||.::  ..|.::::.
  Fly   878 --------SG----PKRCPDPLVFDVNDPMHLDFIYAAANLRAEVYGIEQVRNRETIAELVQKVK 930

  Fly   363 LPADSIDERS-VRLICKEAAGLAVIRG---------------TRIAEEYEKSSRLLPLVEDNELQ 411
            :|  ....|| |::...|||..|....               :.:.:..:|||::.||..:.:..
  Fly   931 VP--EFKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKIISELLKNADKSSKITPLEFEKDDD 993

  Fly   412 GNLTAYNFALRAYERFLSECGNI--PGECIVEQDIGRLKSIAAKMLSDLGMHATISDDVLHEICR 474
            .||         :..|:..|.|:  ....|...|..:.|.||.|::..:.
  Fly   994 SNL---------HMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIA--------------- 1034

  Fly   475 YGGAELHAVSAFIGGCAAQEVIKII 499
                   ..::.:.|.|..||||:|
  Fly  1035 -------TTTSVLSGLAVLEVIKLI 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	99/545 (18%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	39/160 (24%)
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	99/545 (18%)
		Ube1_repeat1	199..574	CDD:238768
		E1_4HB	447..510	CDD:292809
		Ube1_repeat2	606..1144	CDD:238767	92/525 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10953
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840