DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP-BP1 and Uba1

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001014102.1	Gene:	Uba1 / 314432	RGDID:	1359327	Length:	1058	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	102/523 - (19%)
Similarity:	171/523 - (32%)	Gaps:	173/523 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 YDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLD 82
            |.||:.:.|.....:|:.::|.:..:..:|.|.||.::|.|:...|:.|..|.:..||.:.|:|.
  Rat    55 YSRQLYVLGHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLR 119

  Fly    83 SSYLGKSKALACMQLLQELNPDV-----NGDYVDESADFLLANRPNFFDSFDLVIASN--LNEQT 140
            ...:||::|......|.|||..|     .|..|::           |...|.:|:.:|  |.||
  Rat   120 EEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVED-----------FLSGFQVVVLTNSPLEEQ- 172

  Fly   141 LLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDA--------- 196
             |.:.|......:.|:...:.|:.|.:.....|..::.        |...|.|..|
  Rat   173 -LRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLT--------DSNGEQPLSAMVSMVTKDN 228

  Fly   197 ------LREHLDGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADE 255
                  |.|...|.|....|       .:..|....|.:|.| |...|.......:|     .|.
  Rat   229 PGVVTCLDEARHGFETGDFV-------SFSEVQGMVQLNGCQ-PIEIKVLGPYTFSI-----CDT 280

  Fly   256 ENYEEAIKA--VNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPL 318
            .|:.:.|:.  |:..    :|||            :::.||                     ||.
  Rat   281 SNFSDYIRGGIVSQV----KVPK------------KISFKS---------------------LPA 308

  Fly   319 PGVLPDMTANTDSYIALQHIYRQQALQDADQVYHK-CQEYLKQLALPADSIDERSVRLICKEAAG 382
            ....||... ||    .....|...|....|..|: |.::.:.   |....:|.:..|:.
  Rat   309 SLAEPDFVM-TD----FAKYSRPAQLHIGFQALHQFCAQHNRP---PRPRNEEDATELVT----- 360

  Fly   383 LAVIRGTRIAEEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRL 447
                                                         |::..|......|:||
  Rat   361 ---------------------------------------------LAQAVNARSPPAVQQD---- 376

  Fly   448 KSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIY 512
                           .:.:|::.::......:|..::|||||.|||||:|..:.::.||.....:
  Rat   377 ---------------NVDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYF 426

  Fly   513 NAI 515
            :|:
  Rat   427 DAL 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	102/523 (20%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	41/159 (26%)
Uba1	NP_001014102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		Ube1	49..1055	CDD:273603	102/523 (20%)
		2 approximate repeats. /evidence=ECO:0000255	63..611		99/515 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810