Protein Alignment APP-BP1 and Uba6

DIOPT Version :10

• Sequence 1: NP_648435.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001100683.1
• Gene: Uba6 / 305268
• RGDID: 1308324
• Length: 1053
• Species: Rattus norvegicus
• Alignment Length: 544
• Identity: 111/544 - (20%)
• Similarity: 185/544 - (34%)
• Gaps: 180/544 - (33%)

  Fly     7 KSPELSDKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVK 71
            :|.|:.|  ..|.||..:.|:.....:..:.|.|..:..:|.|.||.|||.||...|:.|....:
  Rat    35 ESLEIDD--GLYSRQRYVLGDTAMQKMAKSCVFLSGMGGLGVEIAKNLVLAGIKALTIHDTKKCQ 97

  Fly    72 EEDLGNNFFL--DSSYLGKSKALACMQLLQELNPDVNGDYV---------DESADFLLANRPNFF 125
            ..|||.||||  |.....:::|.|.:..:.||||     ||         ||:.|.      :|.
  Rat    98 AWDLGTNFFLCEDDVVNERNRAEAVLHRVAELNP-----YVQVSSSSAPFDETTDL------SFL 151

  Fly   126 DSFDLVIASNLNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRL 190
            :.:..|:.:    :|.|.|.:::..      :|.|             ||
  Rat   152 EKYQCVVLT----ETKLTLQKKINN------FCHS-------------HC--------------- 178

  Fly   191 EHPFDALREHLDGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADE 255
             .|...:...:.|                  :|.:...|       :.::.::.:|..||.|  |
  Rat   179 -PPIKFISTDVHG------------------IWSRLFCD-------FGDEFEVSDTTGEEPK--E 215

  Fly   256 ---ENYEEAIKAVNTAFGAGQVPKSLK-----AIFEDDACEQLNKKSNVFWIMAKALKHFVIHEN 312
               .|..:|...:.|..  ...|..|:     ...|.:....||.......:::
  Rat   216 IFISNITQANPGIVTCL--ENHPHKLETGQFLTFREINGMAGLNGSVQQITVIS----------- 267

  Fly   313 EGHLPLPGVLPDMTANTDSY----IALQ----HIYRQQALQDADQVYH-KCQEYLKQLALPADSI 368
                |....:.| |...|.|    ||:|    .|:..:.|:  .|:.| ||        |.||
  Rat   268 ----PFSFSIGD-TTELDPYLHGGIAVQVKTPKIFNFEPLE--SQIKHPKC--------LIAD-- 315

  Fly   369 DERSVRLICKEAAGLAVIRGTRIAEEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGN 433
                   ..|..|.|.:                                :.|:.|.::|......
  Rat   316 -------FSKPEAPLQI--------------------------------HVAMLALDQFQENYSR 341

  Fly   434 IPG-ECIVEQDIGRLKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIK 497
            .|. .|  :||...|..:...:...|.....::.|::|.:.......|..::|.:||.|:|||:|
  Rat   342 KPNIRC--QQDSDELLKLTICISETLEEKPEVNADIVHWLSWTAQGFLPPLAAAVGGVASQEVLK 404

  Fly   498 IITKQYKPIDN-TFIYNAITTESV 520
            .:|.::.|:.. .::..|.|.||:
  Rat   405 AVTGKFSPLCQWLYLEAADTVESL 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_648435.1	APPBP1_RUB	16..522	CDD:238770	108/535 (20%)
Uba6	NP_001100683.1	Ube1	38..1046	CDD:273603	110/541 (20%)