DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP-BP1 and Uba6

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001100683.1	Gene:	Uba6 / 305268	RGDID:	1308324	Length:	1053	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	111/544 - (20%)
Similarity:	185/544 - (34%)	Gaps:	180/544 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KSPELSDKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVK 71
            :|.|:.|  ..|.||..:.|:.....:..:.|.|..:..:|.|.||.|||.||...|:.|....:
  Rat    35 ESLEIDD--GLYSRQRYVLGDTAMQKMAKSCVFLSGMGGLGVEIAKNLVLAGIKALTIHDTKKCQ 97

  Fly    72 EEDLGNNFFL--DSSYLGKSKALACMQLLQELNPDVNGDYV---------DESADFLLANRPNFF 125
            ..|||.||||  |.....:::|.|.:..:.||||     ||         ||:.|.      :|.
  Rat    98 AWDLGTNFFLCEDDVVNERNRAEAVLHRVAELNP-----YVQVSSSSAPFDETTDL------SFL 151

  Fly   126 DSFDLVIASNLNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRL 190
            :.:..|:.:    :|.|.|.:::..      :|.|             ||
  Rat   152 EKYQCVVLT----ETKLTLQKKINN------FCHS-------------HC--------------- 178

  Fly   191 EHPFDALREHLDGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADE 255
             .|...:...:.|                  :|.:...|       :.::.::.:|..||.|  |
  Rat   179 -PPIKFISTDVHG------------------IWSRLFCD-------FGDEFEVSDTTGEEPK--E 215

  Fly   256 ---ENYEEAIKAVNTAFGAGQVPKSLK-----AIFEDDACEQLNKKSNVFWIMAKALKHFVIHEN 312
               .|..:|...:.|..  ...|..|:     ...|.:....||.......:::
  Rat   216 IFISNITQANPGIVTCL--ENHPHKLETGQFLTFREINGMAGLNGSVQQITVIS----------- 267

  Fly   313 EGHLPLPGVLPDMTANTDSY----IALQ----HIYRQQALQDADQVYH-KCQEYLKQLALPADSI 368
                |....:.| |...|.|    ||:|    .|:..:.|:  .|:.| ||        |.||
  Rat   268 ----PFSFSIGD-TTELDPYLHGGIAVQVKTPKIFNFEPLE--SQIKHPKC--------LIAD-- 315

  Fly   369 DERSVRLICKEAAGLAVIRGTRIAEEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGN 433
                   ..|..|.|.:                                :.|:.|.::|......
  Rat   316 -------FSKPEAPLQI--------------------------------HVAMLALDQFQENYSR 341

  Fly   434 IPG-ECIVEQDIGRLKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIK 497
            .|. .|  :||...|..:...:...|.....::.|::|.:.......|..::|.:||.|:|||:|
  Rat   342 KPNIRC--QQDSDELLKLTICISETLEEKPEVNADIVHWLSWTAQGFLPPLAAAVGGVASQEVLK 404

  Fly   498 IITKQYKPIDN-TFIYNAITTESV 520
            .:|.::.|:.. .::..|.|.||:
  Rat   405 AVTGKFSPLCQWLYLEAADTVESL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	108/535 (20%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	43/164 (26%)
Uba6	NP_001100683.1	Ube1	38..1046	CDD:273603	110/541 (20%)
		Ube1_repeat1	43..428	CDD:238768	107/532 (20%)
		E1_4HB	298..358	CDD:292809	19/112 (17%)
		Ube1_repeat2	462..1005	CDD:238767
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810